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Chikungunya virus (CHIKV) is a re-emerging arbovirus causing acute febrile illness and chronic debilitating arthritis, thereby imposing significant global public health and economic burdens. While robust immune responses involving inflammatory cytokines and immune cell infiltration …
Read PDFUnderstanding how individual cancer cells adapt to drug treatment is a fundamental challenge limiting precision medicine cancer therapy strategies. Here, we present a multimodal framework that integrates bulk and single-cell treated and untreated transcriptomics data …
Read PDFEggshell quality is a major concern in the poultry industry. The speckle phenotype in eggshell affects eggshell color, thickness, and Haugh Unit (HU) and significantly affects the hatchability rate. The rate of speckled eggs increases …
Read PDFSenescence is a critical risk factor for the development of triple-negative breast cancer (TNBC), yet its specific impact on the disease remains inadequately understood. This study aims to elucidate the role of pivotal genes in …
Read PDFNeuropsychiatric Systemic Lupus Erythematosus (NPSLE) represents one of the most severe and enigmatic manifestations of SLE, contributing significantly to disease morbidity and mortality. Its clinical presentation is profoundly heterogeneous, encompassing 19 distinct syndromes that pose …
Read PDF[This corrects the article DOI: 10.3389/fimmu.2026.1744845.].
Read PDFBACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium during the implantation window remains …
Read PDFUnderstanding how genetic risk variants contribute to respiratory diseases requires mapping genome-wide association study (GWAS) signals to disease-relevant cell types and states within the human lung. Here, we integrated GWAS summary statistics for ten major …
Read PDF<h4>Background</h4>Multiple myeloma (MM) typically evolves from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Its progression is accompanied by significant tumor heterogeneity and immune microenvironment remodeling, and MM remains largely incurable despite …
Read PDFArchaea and Bacteria are two fundamentally distinct domains of life that share prokaryotic traits, yet differ markedly in molecular and cellular architecture. While many archaeal species identified thus far have been found in extreme environments, …
Read PDF<h4>Background</h4>Patients undergoing lung cancer surgery experience significant systemic inflammatory responses and anesthetic interventions during the perioperative period, which can affect immune status and the tumor microenvironment. Different anesthetic techniques variably regulate inflammation, cytokine signaling, and …
Read PDF<h4>Background</h4>Immune cells critically influence pituitary neuroendocrine tumor (PitNET) progression and therapeutic responses. However, their composition and functional dynamics remain unclear. This study aimed to delineate the immune heterogeneity and intercellular communication networks within PitNETs.<h4>Methods</h4>This study …
Read PDFDrug discovery remains a protracted and capital-intensive process, primarily hindered by inefficiencies in drug screening. Microfluidic technology provides a promising approach for <i>in vitro</i> drug screening, enabling physiologically relevant, high-throughput, and cost-effective analysis by mimicking …
Read PDFSingle-cell RNA sequencing (scRNA-seq) in multi-condition experiments enables the systematic assessment of treatment effects. Analyzing scRNA-seq data relies on linear dimensionality reduction (DR) methods like principal component analysis (PCA). These methods decompose high-dimensional gene expression …
Read PDFCardiac fibroblasts (CFs) are key mediators of heart repair following myocardial infarction (MI). A specific CF subpopulation, termed Reparative Cardiac Fibroblasts (RCFs), has been shown to orchestrate scar formation and prevent ventricular rupture after MI. …
Read PDF<h4>Background</h4>Electrophysiological features of glioblastoma cells (GBCs) remain largely elusive, challenging our comprehension of glioblastoma pathophysiology. Spiking GABAergic-oligodendrocyte-progenitor (OPC) tumor cells were recently described in IDH-mutant glioma, correlating with prolonged patient survival. Here, we characterize single-cell …
Read PDF<h4>Background</h4>Osteosarcoma (OS) is a malignant primary bone tumor developing from primitive mesenchymal cells. Glycosylation is important in the adhesion, metastasis and transformation of cancer cells. Nevertheless, the investigation of glycosylation-related genes (GRGs) in OS has …
Read PDFSingle-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic research, enabling the creation of detailed tissue, organ, and species-level atlases for model organisms. In Hydractinia, a cnidarian model for stem cell and regeneration studies, recent atlases have …
Read PDF<h4>Introduction</h4>Intra-tumoural heterogeneity contributes to treatment resistance and disease progression in cancer. Single-cell RNA sequencing (scRNA-seq) enables profiling of cellular diversity in the tumour microenvironment. However, current protocols for generating single-cell 3'gene expression data require intact …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors globally, with liver cirrhosis (LC) recognized as a significant precursor. Xenobiotic metabolism plays a pivotal role in liver diseases, where the liver's primary function …
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