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Garuga floribunda var. gamblei (King ex W. W. Sm.) Kalkman, a tree species of Burseraceae (Sapindales), is rare in China and prized for its high-quality timber. Despite its economic and ecological significance, genetic architecture remains …
Read PDFIdentification of protein-bound DNA sites is key to understanding genome function and regulation, but studying protein-DNA interactions in living, unperturbed cells remains challenging. UV footprinting has been used to study such interactions in vivo by …
Read PDFFinger millet (<i>Eleusine coracana</i> (L.) Gaertn.) is a resilient yet underutilized cereal with exceptional potential to withstand adverse environmental conditions. Despite its adaptability, the genetic and physiological bases of its stress tolerance remain insufficiently characterized …
Read PDFThe California poppy (Eschscholzia californica), a native wildflower of western North America and the state wildflower of California, is characterized by extensive ecological variation and adaptation to diverse climatic conditions. Its broad geographic range and …
Read PDFPublic infrastructures for human genomic data are increasingly incorporating federated approaches alongside centralized and cloud-native models, yet operational federation remains constrained by unsolved challenges at the legal, semantic, and technical layers. We describe the current …
Read PDFThis paper presents a deep-learning framework that combines an LSTM, a graph neural network (GNN), and transformer-style attention to model genotype-environment (G×E) effects for maize yield prediction. Weather data for a growing season is summarized …
Read PDFShoot flushing is a critical determinant of grafted seedling quality in Camellia oleifera, with key evaluation metrics including flushing timing, new shoot number and growth rate, and seedling height uniformity. To elucidate the molecular mechanisms …
Read PDFForensic DNA analysis has already influenced criminal justice, and serves as a powerful tool for both conviction and exoneration. Despite its scientific foundations and wide application, DNA evidence is vulnerable to interpretive errors, methodological limitations, …
Read PDFLarge-scale genomic rearrangements are prevalent in cancer genomes and can profoundly rewire three-dimensional (3D) genome architecture, leading to aberrant oncogene activation through enhancer hijacking. The rewired 3D organization generates unique chromatin contact signatures, which can …
Read PDFWe investigate the ability of vision-language models (VLMs) to extract structural region definitions from rasterized multiple sequence alignment (MSA) images, as part of the PDB-Descriptome project. Using synthetic MSAs with annotated structural biological entities (SBEs) …
Read PDF<h4>Background</h4>While evidence linking the gut microbiome (GM) to cancer immunotherapy is growing, data regarding its role in chemotherapy remains limited. This study aims to investigate the effect of chemotherapy on GM composition and its potential …
Read PDF[This corrects the article DOI: 10.3389/fmicb.2026.1800013.].
Read PDFBACKGROUND: Statins are widely prescribed lipid-lowering agents, but their use is associated with an increased risk of new-onset type 2 diabetes mellitus (NO-T2DM) ranging from 9% to 13%. While genetic variants in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), …
Read PDFBACKGROUND: Group A streptococcus (GAS) could lead to various disease types in children, but central nervous system (CNS) infections are uncommon. In this paper, we analyzed the clinical features of a GAS case with meningitis …
Read PDFThe genus <i>Kluyvera</i> (<i>Enterobacteriaceae</i>) comprises gram-negative, motile, non-spore-forming rods. <i>Kluyvera sichuanensis</i> strain 142937 was isolated in this study from biliary drainage fluid. The draft genome sequence of this clinical strain was determined to be approximately …
Read PDFMultiple germline and somatic genomic factors are associated with risk of coronary artery disease, but there is no single measure of risk that integrates all information from a DNA sample. To address this gap, we …
Read PDFIn this commentary, we describe how the Clinical Genome Resource's (ClinGen's) application programming interface-based microservices accelerate growth and dissemination of knowledge about human genetic variation. By exposing findable, accessible, interoperable, reusable, and AI-ready variant data, …
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