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<h4>Introduction</h4>Thyroblastoma is a rare and highly aggressive embryonal thyroid malignancy typically associated with DICER1 alterations. However, DICER1-wildtype cases remain poorly characterized at the molecular level.<h4>Methods</h4>We report a case of aggressive thyroblastoma in a 62-year-old male, …
Read PDFDNA methylation is a key regulator of eukaryotic genomes, most commonly through 5-methylcytosine (5mC). In contrast, the existence and function of N<sup>6</sup>-methyladenine (6mA) in eukaryotes have been controversial, with conflicting reports resulting from methodological artifacts. …
Read PDF<i>Bacillus cereus</i> HS120 was isolated from the stomach of a healthy hilsa (<i>Tenualosa ilisha</i>) in Nabogonga River, Bangladesh. Here, we present a 5,673,590-bp draft genome with 35.23 % GC content, which encodes numerous biosynthetic gene …
Read PDFEndogenous DNA damage from metabolism and genome dynamics drives mutation, instability, and disease. New insights from ACS Fall 2025 reveal chemical diversity, metabolic drivers, and repair limits that shape cancer risk and biomarker development.
Read PDFThe Yarkand hare (Lepus yarkandensis) is endemic to the Tarim Basin in Xinjiang, China. It is a key species and a critical component of the Tarim Basin ecosystems. However, the lack of a reference genome …
Read PDFLong-read sequencing data is useful for detecting large and complex structural variations; however, technical artifacts can lead to false structural variant calls. In our analyses, we became aware of a foldback artifact in long-read data. …
Read PDFHealthcare, and the world at large, are currently facing an antibiotic crisis caused by the increase in antibiotic resistant bacterial pathogens, combined with divestment in the drug discovery pipeline for new antibiotics. The Tiny Earth …
Read PDF<i>Aeromicrobium</i> sp. JP4, an efficient degrader of polyurethane plastic, was isolated from a plastic waste dumpsite of Nanjing City, Jiangsu Province, China. We report the complete genome sequence of strain JP4, which consists of a …
Read PDFMobile genetic elements (MGEs) play a central role in the acquisition and dissemination of antibiotic resistance genes (ARGs). This study analyzed the distribution of MGEs using the whole-genome sequences of 38 <i>Acinetobacter</i> isolates from patient, …
Read PDFSalicornia depressa (American pickleweed) is the most widespread member of its salt-loving genus in North America. Pickleweeds typically colonize high marsh areas that tides make highly saline. Most other salt marsh plants cannot withstand the …
Read PDFBACKGROUND: Traditionally, Pseudonectria foliicola has been considered to have high host specificity, mainly infecting boxwood and causing typical leaf spot disease, with little threat to human health. However, in 2024, the first case of human …
Read PDF<h4>Background</h4>To determine the prognosis of osteosarcoma, multiple predictive models have been constructed in recent years. Nevertheless, the model for N6-methyladenosine (m<sup>6</sup>A)-related genes, a critical subset of molecular regulators for osteosarcoma, has not been identified.<h4>Methods</h4>Gene expression …
Read PDFData quality is the foundational to scientific research and the rapid advancement of artificial intelligence. Ensuring data quality, provenance, and reproducibility requires robust mechanisms for traceability and accountability from the moment data are created. We …
Read PDFBACKGROUND: Microsporidia sp. MB is an intracellular parasite of anopheline mosquitoes identified across the African continent. Microsporidia sp. MB infections appear to have no significant effect on mosquito fitness and can vertically transmit, whilst infected …
Read PDFBladder cancer is a challenging disease with high recurrence rates and limited treatment options. Studies have highlighted the role of ferroptosis, an iron‑dependent cell death mechanism, in cancer progression and treatment. In the present study, …
Read PDFGDSL esterase/lipase (GELP) proteins constitute an evolutionarily conserved yet functionally diversified hydrolase family in land plants. They participate in cuticle and secondary cell wall biosynthesis, seed lipid remobilization, reproductive development, and hormone-mediated responses to biotic …
Read PDFUnderstanding the molecular mechanisms underlying disease resistance in Salmo trutta fario is of fundamental importance for enhancing the health and sustainability of salmonid aquaculture. In this study, we performed an integrative multi-omics analysis combining transcriptome …
Read PDF<h4>Background</h4>Traditional infectious disease surveillance systems face significant limitations, including delayed detection, underreporting of asymptomatic cases, and inequitable health care access. Wastewater-based epidemiology (WBE), enhanced with genomic analysis, offers a noninvasive and cost-effective alternative for early …
Read PDFPacific herring (<i>Clupea pallasii</i>) serve as a critical trophic link between plankton and many marine species targeted by fisheries. With a broad distribution throughout the North Pacific Ocean, from the Arctic to temperate latitudes, herring …
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