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Full text 2026

Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations

Zhang H, Zhang P, Bindels E, et al.

Pooled CRISPR screening combined with single-cell RNA sequencing (scRNA-seq) has emerged as a powerful strategy for dissecting gene function and reconstructing gene regulatory networks (GRNs) in complex biological systems. This approach enables high-throughput, parallel perturbation …

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Transcriptomics
Full text 2026

A sorghum-anchored pan-grass syntenic gene set in grasses

Dias HM, Sagawa GYA, Torres-Rodriguez VJ, et al.

Understanding orthologous and homeologous relationships among genes informs how evolution and artificial selection have shaped plant genomes of related species to adapt to different niches and produce diverse phenotypes. Grasses are ecologically and economically important …

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Bioinformatics
Full text 2026

From High-Density Genomic Mapping to Precision Molecular Breeding: A Comprehensive Review of <i>Capsicum</i> Genomic Resources

Wang L, Kan J, Zhong W, et al.

The genus <i>Capsicum</i> comprises several species that are vital vegetable and spice crops cultivated worldwide, possessing significant economic, nutritional, and ornamental value due to their diverse fruit morphologies, colors, spiciness levels, and stress resistance. Historically, …

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Genome Assembly Nanopore Sequencing Structural Variants
Full text 2026

Streptococcus didelphis infection in free-ranging white-eared opossum (Didelphis albiventris) and Brazilian common opossum (Didelphis aurita): pathology, microbiologic, and genomic characterization

Santos DOD, Castro YG, Vieira AD, et al.

Marsupials of the genus Didelphis are highly adapted to urban environments and are widely distributed in the Americas. Streptococcus didelphis is a bacterium that has been isolated from, and associated with disease, in the Virginia …

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Bioinformatics
Full text 2025

Genomics in Epidemiology and Disease Surveillance: An Exploratory Analysis

Tiwari S, Dhakal T, Kim BJ, et al.

Genomics has revolutionized epidemiology and disease surveillance by providing powerful tools for identifying, tracking, and analyzing pathogens at the molecular level. This exploratory analysis examines the integration of genomic with traditional epidemiological approaches, highlighting the …

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Bioinformatics
Full text 2026

The Role of Genomics in Advancing and Standardising Bacteriophage Therapy

Abdraimova N, Shitikov E, Kornienko M.

Bacteriophage therapy, which employs bacterial viruses to selectively eliminate pathogenic bacteria, has re-emerged as a promising strategy in the face of increasing antimicrobial resistance. However, its widespread clinical implementation is constrained by concerns regarding safety, …

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Bioinformatics
Full text 2025

Structured RDF dataset for genomic feature extraction and detection of biotechnological microorganisms of the &lt;i&gt;Burkholderia&lt;/i&gt; genus

Osuna-González R, De Ita Luna G, Valdovinos-Rosas RM, et al.

The current dataset has been built from 200 genomes of <i>Burkholderia</i> genus microorganisms in GenBank Flat File (GBFF) format, with information obtained from the National Center for Biotechnology Information (NCBI). Python scripts were developed to …

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Bioinformatics