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<h4>Background</h4>To evaluate whether integrating proteomics, metabolomics, and a cardiovascular disease specific polygenic risk score (CVD-PRS) in the SCORE2-Diabetes model improves sex-specific 10-year prediction of major adverse cardiovascular events (MACE) in individuals with type 2 diabetes …
Read PDFFeed additives play a crucial role in boosting livestock immunity, but their underlying molecular mechanisms are often incompletely understood. This study used integrated proteomics and metabolomics to systematically investigate the immunomodulatory effects of dietary fermented …
Read PDFBACKGROUND: Acute catecholamine-induced myocardial stress contributes to several cardiac conditions, including takotsubo syndrome (TS), a life-threatening acute cardiac syndrome characterized by transient regional left ventricular dysfunction that lacks evidence-based therapy. Extracellular vesicles (EVs) reflect active …
Read PDFProteases are common components of extracellular vesicles (EVs), yet the extent and functional relevance of ongoing proteolytic activity on EV surfaces remain largely unexplored. Such activity could significantly influence EV function and identity, with likely …
Read PDF<h4>Background</h4>Amniotic fluid exosomes (AF-Exos) are pivotal carriers of biological information during fetal development; however, their role in 22q11.2 Deletion Syndrome (22q11.2DS) remains unclear. To elucidate the molecular mechanisms underlying fetal anomalies in 22q11.2DS, this study …
Read PDFApolipoprotein E4 (<i>APOE4</i>) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in <i>APOE4</i> carriers, the …
Read PDF<h4>Background</h4>Bowel resection is required in up to 27% of inflammatory bowel disease (IBD) patients due to severe complications. Identifying reliable predictors for future surgery is crucial for risk stratification and management.<h4>Materials and methods</h4>We retrospectively analyzed …
Read PDFProtein expression within oncogenic or suppressive pathways is a hallmark indicator of oncogenesis. While traditional AI models in digital pathology attempt to predict singular proteins, there is a need to predict the downstream expression of …
Read PDFPrimary cilia in radial glia act as signaling hubs essential for brain development, yet their molecular roles remain poorly understood. Here, using proximity-labeling-mediated in vivo proteomics, we systematically mapped ciliary proteins in the developing telencephalon. …
Read PDFHuman activities such as industrialization, recreation, domestic water use, agriculture, and energy production have significantly increased pollution in water bodies, especially within urban regions. This pollution affects ecological biodiversity, exerting broad impacts on various environmental …
Read PDFBerberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear. Based on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones …
Read PDF<h4>Motivation</h4>Exploration of large-scale biological datasets remains a central challenge in computational biology. While many tools are available, they are often developed in isolation, leading to fragmented workflows, duplicated efforts, and limited reproducibility. There is a …
Read PDFMicroproteins (≤70 amino acids) have important and often essential roles in all kingdoms of life, influencing cell motility, regulation of membrane transport and as transcription factors. In the halophilic archaeon and model system <i>Haloferax volcanii</i> …
Read PDFPlasma proteomics is a rapid, noninvasive, and highly informative approach for identifying disease biomarkers. However, the wide dynamic range of protein concentration limits the depth of liquid chromatography-tandem mass spectrometry proteomics. To address this challenge, …
Read PDF<h4>Background</h4>Polycystic ovary syndrome (PCOS) is a complex and heterogeneous metabolic disorder that affects 6-20% of women of reproductive age. However, research on the lactylation-modified proteome in PCOS remains limited.<h4>Methods</h4>This study included 30 patients with PCOS …
Read PDF<h4>Background</h4>Canine oral cancers are difficult to manage due to complex biology and a lack of non-invasive biomarkers. Proteomic approaches, particularly gel-based liquid chromatography-tandem mass spectrometry (GeLC-MS/MS), have been used on tissue and saliva, but serum …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) is a major cause of morbidity and mortality, with chronic inflammation from inflammatory bowel disease (IBD) representing a well-established risk factor. Clarifying shared molecular mechanisms may facilitate early detection and prevention strategies.<h4>Methods</h4>Proteomic …
Read PDF<h4>Background</h4>Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and …
Read PDFRecent high-throughput applications to shotgun proteomics have shown great benefits of coupling ion mobility spectrometry (IMS) to mass spectrometry. IMS adds a separation dimension by differentiating biomolecules from their size and shape. We (and others) …
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