Search the literature by keyword, topic, or author. Filter to articles with full text available.
10297 results
(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify …
Read PDFBuilding custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models (LLMs) and autonomous coding agents can dramatically lower this barrier …
Read PDFNo abstract available.
Read PDFNext-generation mass spectrometry platforms (Orbitrap Astral, timsTOF Ultra) are reshaping proteomics by enhancing analytical depth and sensitivity. We compared these platforms against Orbitrap Exploris 480 using neonatal mouse lung tissues from a bronchopulmonary dysplasia model …
Read PDFThis dataset contains mass spectrometry-based proteomic profiles of human brain organoids cultured on Earth for 30 days, then maintained aboard the International Space Station (ISS) for an additional 30 days, with matched ground controls that …
Read PDF<h4>Objective</h4>More and more evidence indicates that type 2 diabetes mellitus (T2DM) can cause muscle lesions and lead to the occurrence of sarcopenia. The changes in the gastrocnemius muscle of T2DM rats were investigated by using …
Read PDFMolecular glue degraders (MGDs) are an emerging class of small molecules that promote selective protein degradation by inducing neomorphic interactions between E3 ubiquitin ligases and non-native substrates, referred to as neosubstrates. Clinically validated examples include …
Read PDFThe current paradigm in synthetic biology for lignin bioconversion platforms includes primarily bacteria and filamentous fungi. Yeast are notoriously understudied for their role in lignin degradation and utilization, despite their ubiquity in saprophytic microbial communities. …
Read PDFCoronary microvascular disease (CMVD) is an underdiagnosed but significant contributor to the burden of ischemic heart disease, characterized by angina and myocardial infarction. The development of risk prediction models such as polygenic risk scores (PRS) …
Read PDFChildhood illnesses from infectious diseases in low- and middle-income countries contribute substantially to the global under-five mortality. Many hospitalized children experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. However, targeted interventions remain elusive …
Read PDF<h4>Background</h4>Proteins and RNA circulate in plasma and can offer insights into human physiology. Yet, despite their clinical importance, direct comparisons between these analytes remain unexplored.<h4>Methods</h4>Here, we measure and compare plasma cell-free RNA (cfRNA) and protein …
Read PDFMOTIVATION: Cancer progression and treatment responses are governed by intricate and dynamic molecular interactions. Although differential network analysis offers considerable potential for identifying condition-specific changes in protein-protein interactions, existing methods primarily rely on static comparisons …
Read PDFMethylglyoxal (MGO) is a reactive metabolic byproduct of glycolysis shown to accumulate in highly glycolytic cells such as cancer cells. MGO reacts with proteins to form covalent adducts in a process termed glycation, and MGO-glycation …
Read PDFThis study presents a comparative analysis of three LysC endopeptidase homologues from <i>Achromobacter lyticus</i> (<i>A. lyticus</i>),<i>Pseudomonas aeruginosa</i> and <i>Lysobacter enzymogenes</i> for mass spectrometry-based proteomics. Utilizing a protein aggregation capture workflow with HeLa cell lysates, we …
Read PDFUnderstanding intratumoral heterogeneity is essential for elucidating tumor biology. Compared to RNA expression, omics-level characterization of cell-type-specific protein expression remains a technical challenge. Bulk mass spectrometry (MS) provides abundant proteomics resources to infer cell-type specificity …
Read PDFExtracellular vesicles (EVs) have gained increasing attention with their intriguing biological functions and their molecular cargoes serving as potential biomarkers for various diseases, including cancers. A relatively lower abundance of EV proteins compared to cellular …
Read PDF<h4>Background</h4>Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are chronic liver diseases characterized by lipid accumulation and persistent inflammation, often progressing to fibrosis or hepatocellular carcinoma (HCC). Hepatitis C virus (HCV) infection …
Read PDF