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<b>Background</b>: Postmenopausal osteoporosis (PMOP) is a common metabolic bone disorder characterized by disrupted bone remodeling due to estrogen deficiency. Erxian Decoction (EXD), a traditional Chinese medicine formula, has shown clinical efficacy against PMOP, but its …
Read PDFPost-translational modifications (PTMs) contribute greatly to the diversity of the human proteome by affecting protein structure, function, interactions, stability, localization, and more. The study of PTMs is essential to understand various cellular functions, disease mechanisms, …
Read PDFHigh-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitivity, and scalability for analyzing large sample cohorts. …
Read PDFMyocardial ischemia-reperfusion injury (MIRI) significantly limits the clinical benefits of reperfusion therapy, underscoring a pressing need for effective interventions. This study examines the cardioprotective effects and underlying mechanisms of the natural amide alkaloid N-<i>p</i>-<i>trans</i>-Coumaroyltyramine (p-CT). …
Read PDFMetabolic syndrome (MetS) has been associated with migraine, but the prediagnostic phase and the molecular features preceding migraine onset remain unclear. We aimed to identify a diagnosis-anchored proteomic variability window and to characterize pathways, candidate …
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Read PDFBACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease (ILD) with limited treatment options and poor prognosis. Differentiating IPF from connective tissue disease–associated ILD (CTD-ILD) is clinically challenging due to overlapping features, …
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Read PDF<h4>Introduction</h4>Understanding the behavioral differences between invasive and non-invasive methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is essential for unraveling infection mechanisms and identifying biomarkers with translational potential. This study compared the proteomic and metabolomic profiles of MRSA isolates …
Read PDFNatural killer (NK) cells contribute to the innate immune system and are pivotal for the defence against opportunistic pathogens, including fungi. <i>Aspergillus fumigatus</i> (AF), a filamentous mold, can cause invasive pulmonary aspergillosis in immunocompromised patients, …
Read PDFBACKGROUND: Analysing large-scale mass spectrometry-based complex proteomics datasets often overwhelm desktop computational resources and require manual configuration for analysis. While FragPipe delivers rapid peptide identification across diverse sample preparation and acquisition modes (DDA, DIA, TMT), …
Read PDFThe comorbidity of chronic pain and mood disorders poses a clinical challenge involving neurobiological mechanisms within key brain regions like the ventral tegmental area (VTA). We employed a multidisciplinary approach in male mice, combining proteomics, …
Read PDF<h4>Background</h4>Gambogic acid (GA) is a natural bioactive compound derived from Garcinia hanburyi Hook. F, has proven anticancer activity and is currently in Phase II clinical trials for the treatment of cancer. However, the molecular mechanisms …
Read PDFNanoflow electrospray ionization is commonly used for proteomics due to its high sensitivity. Signal intensity, however, is dependent on optimal emitter positioning relative to the mass spectrometer inlet. Here, we characterize the effect of varied …
Read PDF<h4>Background</h4>Previous investigations have shown that the absence of typical breast symptoms is associated with unfavorable outcomes after an acute myocardial infarction (AMI). Delayed diagnosis and therapy could not explain these results, so other causes seem …
Read PDFMoyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive stenosis of large intracranial arteries and formation of fragile collateral vessels that can be triggered by a broad range of genetic and immune factors. …
Read PDFWith the continuous rise in antibiotic resistance, novel methods that can reveal currently unknown antibiotic resistance mechanisms are essential to prepare and inform health responses and novel antibiotic discovery campaigns. Here, we built a library …
Read PDFThe subcellular localisation of proteins is a key determinant of their function. High-throughput analyses of these localisations can be performed using mass spectrometry-based spatial proteomics, which enables us to examine the localisation and relocalisation of …
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