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Atherosclerosis is a chronic metabolic disorder driven by endothelial dysfunction, inflammation, oxidative stress, and progressive plaque remodeling; processes amplified in type 2 diabetes. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally developed for glycemic control, have emerged …
Read PDFAs global populations age rapidly, extending healthy lifespan has become a major public health priority. Physical exercise is widely recognized as a key strategy to slow functional decline and promote healthy aging, but its effectiveness …
Read PDF<b>Objectives:</b> Diminished ovarian reserve (DOR) significantly compromises in vitro fertilization (IVF) success. Although systemic markers such as anti-Müllerian hormone (AMH) serve as valuable clinical indicators of the ovarian reserve, they lack the sensitivity to reflect …
Read PDF<h4>Background</h4>PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition is a potent cholesterol-lowering strategy. This study examined the effects of PCSK9 monoclonal antibodies (mAbs) and high-intensity statins beyond low-density lipoprotein cholesterol reduction, which are not fully defined, …
Read PDFReduction of disulfide bonds in proteins followed by selective modification of Cysteine (Cys) residues is a common practice in proteomics experiments to facilitate digestion into peptides and ultimately identification by mass spectrometry (MS). Due to …
Read PDF<h4>Purpose</h4>Clinical proteomics enhances our understanding of biological functions and pathological processes. Since the localization of various protein clusters within the cornea is still unknown, a spatial model of the human corneal proteome was established.<h4>Methods</h4>In this …
Read PDFMedulloblastoma is one of the most prevalent pediatric brain tumors. Currently, existing therapies for this devastating type of cancer can only prolong survival time with severe side-effects and relapse. These therapies are not curative for …
Read PDF<h4>Background</h4>Leptomeningeal metastasis (LM) is a fatal complication of advanced cancer with limited therapeutic options and poor prognosis. Immune checkpoint inhibitors (ICIs) have shown promise in systemic disease, but intrathecal ICIs efficacy and immunological impact in …
Read PDFThe microbial cell wall is a dynamic structure responsible for maintaining the shape and integrity of the cell. It is involved in the processes of cell growth, reproduction and division, protection against environmental stress factors, …
Read PDFMultimorbidity of cardiometabolic disease (CMD) and cancer is a growing but understudied global challenge in an aging world. Here, we perform multistate analysis in 429,555 UK Biobank participants to investigate transition patterns, identify multiomics signatures, …
Read PDFSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and immune dysregulation, predominantly affecting women of reproductive age. Current treatments, including antimalarials, corticosteroids, and immunosuppressants, often entail long-term toxicity. To address …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) is the third most common cancer worldwide. Advanced CRC has a grim prognosis, so there is a high demand for an early non-invasive diagnostic biomarker.<h4>Methods</h4>We present a colorectal tissue-serum proteomics approach combined …
Read PDFThe marine environment is a rich source of natural products that, as promising bioactive compounds, demonstrate environmentally friendly potential for application across various industries [...].
Read PDFCellular lipid metabolism is subject to strong homeostatic regulation, but the players involved in and mechanisms underlying these pathways remain largely uncharacterized. Here we develop a 'feeding-fishing' approach coupling membrane editing using optogenetic lipid-modifying enzymes …
Read PDFHepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with late-stage diagnoses predominantly driven by the absence of early clinical symptoms and the inadequate sensitivity of current diagnostic tools, highlighting a critical unmet …
Read PDFPolyploid crops such as wheat, Brassica, and cotton are critical in the global agricultural and economic system. However, their productivity is threatened increasingly by biotic stresses such as disease, and abiotic stresses such as heat, …
Read PDFMass spectrometry (MS) is indispensable for high-throughput quantitation of protein expression. But protein function is regulated by factors beyond abundance alone. Here, we evaluate two supercharging reagents, dimethyl sulfoxide (DMSO) and m-nitrobenzyl alcohol (mNBA), in …
Read PDFIn proteome studies, the application of alternative proteases, exclusively or in addition to trypsin, often increases protein sequence or proteome coverage. It has recently been shown that, in particular, the analysis of small proteins benefits …
Read PDFThe Hevea brasiliensis is the only commercial source of natural rubber. In natural rubber production, exogenous ethylene is widely used as a stimulant for increasing rubber latex yield. To reveal the potential regulation mechanisms for …
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