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Extracellular vesicles (EVs) are central to intercellular communication and have gained attention as rich sources of molecular information in cancer research, but their molecular composition remains incompletely characterized. Protein glycosylation is a frequent post-translational modification; …
Read PDFCells continuously produce and degrade molecules, essential for maintaining homeostasis. The study of these dynamics has gained momentum since the development of pulse-chase methods, utilizing fluorescent or isotopic labeling to assess properties such as turnover …
Read PDFStress granules (SGs) are membrane-less organelles formed through liquid-liquid phase separation of proteins and RNAs, serving as temporary repositories for biomacromolecules to protect cells under stress conditions. Impaired SG disassembly is closely implicated in neurodegenerative …
Read PDFIntegrating spatial omics with artificial intelligence is likely to advance biomarker research and diagnostics, with the potential to pair mechanistic insight into spatial target biology. By developing scalable, reproducible quantification in routine pathology, it can …
Read PDFDrought stress profoundly impacts agricultural productivity, significantly reducing crop yields and global food insecurity. Consequently, improving crops to develop resistance against drought stress is imperative. To combat the adverse impact of climate change on crop …
Read PDFSaturated fatty acids such as palmitic acid (PA) can induce lipotoxic stress, whereas monounsaturated fatty acids like oleic acid (OA) often promote adaptive responses through lipid droplets (LDs) formation. Here, we reveal that epithelial-mesenchymal transition …
Read PDFTop-down mass spectrometry provides a powerful approach for analyzing and quantifying intact proteoforms, i.e., the distinct molecular forms of proteins. Isobaric labeling-based quantification strategies offer the advantages of multiplexing and increased analytical depth. However, a …
Read PDFPancreatic ductal adenocarcinoma (PDA) remains largely refractory to anti-angiogenic strategies, and non-endothelial perfusion mechanisms such as vasculogenic mimicry (VM, endothelial-like channels formed by tumour cells) may sustain tumour progression. Here, we examined whether the combined …
Read PDFImmune processes play complex roles in Alzheimer’s disease and related dementias (ADRD), but it remains unclear whether host defenses against common microbes also contribute to ADRD, and what underlying mechanisms may account for these relationships. …
Read PDFHighly inflammatory mononuclear phagocytes (MNPs) cause tissue damage across the respiratory tract and other organs in response to infections such as SARS-CoV-2. Extracellular vesicles (EVs) can metabolically and phenotypically reprogram target cells, suggesting a potential …
Read PDFContrast-induced acute kidney injury (CI-AKI) is a major cause of hospital-acquired AKI, but its molecular pathogenesis remains incompletely understood. In this study, we used quantitative 4D proteomics, integrating ion mass-to-charge ratio (m/z), retention time, ion …
Read PDFAccumulating evidence indicates that a hypomagnetic field (HMF, <5 μT) has a significant impact on various organ systems in animals. However, the cellular and molecular mechanisms underlying these biological effects remain unclear. Understanding the molecular …
Read PDFAn insect-associated bacterium, <i>Streptomyces</i> sp. SirexAA-E (SirexAA-E) secretes plant biomass-degrading enzymes depending on the available cell wall materials. SirexAA-E readily utilizes xylan, one of the major hemicelluloses. However, the enzyme composition and pathways supporting xylan …
Read PDFCells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify …
Read PDF<h4>Introduction</h4>Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting carriers of premutation expansions (55-200 CGG repeats) in the fragile X messenger ribonucleoprotein 1 (<i>FMR1</i>) gene. Despite its clinical significance, FXTAS currently lacks reliable …
Read PDFColorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death globally. Most CRCs arise from colorectal adenomas (CRAs), particularly advanced adenomas, which are recognized as critical precancerous …
Read PDFBlood proteins have provided essential insights into how humans responded to the recent pandemic. To expand our understanding beyond patients seeking medical care, we conducted a citizen-centric survey with 2,000 random residents (age: 18-69 years) …
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