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Data-based clustering in prediction of cervical cancer DNA methylation using pan-cancer genetic and clinical data
<h4>Motivation</h4>Understanding the role of DNA methylation in oncogenesis, diagnosis, and treatment requires data sufficient in size and accuracy, but current epigenetic data is limited, especially for population groups underrepresented in research. We propose a framework …
Read PDFDecoding the significance of TERT gene in Polycystic Ovary Syndrome: From molecular mechanisms to emerging diagnostic and therapeutic strategies
Polycystic Ovary Syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age, characterized by hyperandrogenism, anovulation, and polycystic ovary morphology. It is influenced by environmental and genetic factors with high heritability and is …
Read PDFIntegrating genomics as clinical biomarkers in pediatric pulmonology
Respiratory diseases often result from complex interactions between an individual's genetic predisposition and their exposure to various environmental and other risk factors. Here we will briefly review how various types of "omics", particularly epigenomics and …
Read PDFMetabolomic fingerprinting of soft tissues uncovers taxonomic, physiological, and ecological aspects of river fishes
Recent advances in molecular phenotyping have driven the rapid growth of untargeted, multi-dimensional approaches such as epigenomics, transcriptomics, proteomics, and metabolomics. When applied to ecology, these high-throughput omics tools offer powerful new molecular trait descriptors …
Read PDFNutri-Epigenetic Regulation of Vitamin D-Impact on Metabolism and Biological Functions: Narrative Review
Vitamin D deficiency is widespread. It increases the risk of several diseases. Therefore, researchers have long studied the factors that influence vitamin D levels in the body. These include its metabolism, catabolism, transport and binding …
Read PDFThe Emerging Role of Omics-Based Approaches in Plant Virology
Virus infections in plants are a major threat to crop production and sustainable agriculture, which results in significant yield losses globally. The past decade has seen the development and deployment of sophisticated high-throughput omics technologies …
Read PDFCellular Senescence in Keloid Pathology: Mechanisms, Biomarkers, and Potential Therapeutic Targets
A keloid is a benign fibroproliferative cutaneous disorder characterized by excessive extracellular matrix deposition, which is driven by persistent fibroblast proliferation and aberrant wound healing. Its complex pathogenesis involves genetic susceptibility, chronic inflammation, mechanical tension …
Read PDFAndrogen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities
Castration-resistant prostate cancer (CRPC) remains a difficult clinical problem, although androgen deprivation therapy and next-generation androgen receptor (AR) pathway inhibitors have greatly improved patient treatment. CRPC is not simply an androgen-independent disease. In many cases, …
Read PDFDistinct regulatory elements of SLC6A14 expression contribute to modification of cystic fibrosis phenotypes
The SLC6A14 gene on chromosome X modifies disease presentation in individuals with cystic fibrosis (CF). Population studies have revealed distinct proximal and distal SNP clusters associated with gastrointestinal and lung phenotypes, respectively. Given the co-localization …
Read PDFTransplantation immunology: paradigm shift from systemic suppression to microenvironment remodeling and precision modulation
Organ transplantation remains the definitive therapy for end-stage organ failure, yet its long-term success is limited by allograft rejection. Conventional immunosuppressive regimens, while effective against acute rejection, are hampered by non-specific mechanisms that lead to …
Read PDFCross-Generational Integration of Exercise and Nutritional Encoding in Offspring Adipose Genomics
Embryogenesis is a critical process for which nutritional and metabolic signals act as informational cues that shape adipose tissue development and establish long-lasting metabolic health. Emerging evidence indicates that adipose tissue is not a passive …
Read PDFRole of eRNAs in Cardiovascular Diseases
Enhancer RNAs (eRNAs), a class of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression in cardiovascular diseases (CVDs), which are among the leading causes of morbidity and mortality in …
Read PDFThe Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium
On October 22nd, 2025, Brain Aging Symposium took place at Harvard Medical School bringing together leading researchers from academia and partner organizations to discuss recent advances in measuring and monitoring human brain aging trajectories, with …
Read PDFThe Potential of Digital Twins for Pediatric Rare Diseases
Rare diseases affect over 300 million people globally, with approximately 75% manifesting in childhood. Their diagnosis is often delayed and approved treatments are lacking for most of the conditions. Pediatric rare diseases research is further …
Read PDFUrine cf-nucleosomes: A non-invasive window into human physiology and disease
Urine contains fragments of cell-free DNA (cfDNA) that offer molecular insights into processes within the urinary system and the body. It remains unclear whether these fragments exist as chromatin and retain chromatin modifications from their …
Read PDFOsteoclasts affect the anti-cancer activity of NK cells
<h4>Introduction</h4>Non-small cell lung cancer (NSLSC) stem cells (CSCs) have been shown to be responsible for bone metastasis by interacting with osteoclasts (OCs) and creating an immunosuppressive environment in the bone pre-metastatic niche. Now, we investigated …
Read PDFEndothelial heterogeneity shapes shear stress response: a transcriptomic perspective
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