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Mapping the future: bibliometric analysis of omics research trends in non-small cell lung cancer
<h4>Purpose</h4>Omics technologies, such as genomics, transcriptomics, proteomics, and radiomics, play an increasingly important role in the diagnosis and treatment of non-small cell lung cancer (NSCLC). It is, therefore, essential to unveil the research landscape and …
Read PDFEditorial: Epigenetic mechanisms and their involvement in rare diseases, volume II
No abstract available.
Read PDFQuantifying TERT promoter mutations in tumor-derived DNA shed into the oral cavity as a potential biomarker for oral squamous cell carcinoma
<h4>Background</h4>Head and neck squamous cell carcinomas (HNSCC) have high recurrence and poor prognosis, largely due to delayed diagnosis. Identification of somatic mutations and human papillomavirus (HPV) sequences in tumor DNA shed in the oral cavity …
Read PDFRecent Advances in nccRCC Classification and Therapeutic Approaches
Non-clear cell renal cell carcinoma (nccRCC) constitutes a biologically diverse category of renal malignancies. The 2022 WHO classification framework has significantly evolved to incorporate molecularly defined entities alongside traditional histologic subtypes, reflecting the growing recognition …
Read PDFGermline HLA heterozygosity is associated with decreased lung cancer risk
Heterozygosity at human leukocyte antigen (HLA) loci may improve lung cancer immunosurveillance by increasing recognition of the tumor by the immune system. Previous studies utilizing data from population-level biobanks, such as the United Kingdom Biobank …
Read PDFInferring gene-regulatory networks using epigenomic priors
We show improved accuracy in-silico of inference of gene-regulatory network (GRN) structure, resulting from the use of an epigenomic prior network. We demonstrate important use-cases of our proposed methodology by re-analyzing datasets from 12 different …
Read PDFSignificance of Epigenetic Alteration in Cancer-Associated Fibroblasts on the Development of Carcinoma
Cancer-associated fibroblasts (CAFs) are a key constituent of the tumor microenvironment. CAFs may affect the development of tumor cells. The critical role of CAFs in the tumor microenvironment is linked to their epigenetic modifications, as …
Read PDFPolyphenols, aging, and health: What can we expect from the food industry in the technology era?
<h4>Background</h4>Aging is a physiological process characterized by several metabolic changes, oxidative stress and inflammatory processes accumulated throughout life, reflecting in several diseases. Adopting a healthy lifestyle, including a diet rich in polyphenols, can play a …
Read PDFDecoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine
Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy. Precision …
Read PDFTranscriptomics and epigenetic data integration learning module on Google Cloud
Multi-omics (genomics, transcriptomics, epigenomics, proteomics, metabolomics, etc.) research approaches are vital for understanding the hierarchical complexity of human biology and have proven to be extremely valuable in cancer research and precision medicine. Emerging scientific advances …
Read PDFTime to use large-scale biobank databases in health policy and public health research
Large-scale biobank databases link data from thousands of participants and multiple sources such as electronic health records, surveys, imaging, and biomarkers. These data infrastructure research initiatives have the potential to inform health care and public …
Read PDFAssociation between imprinting disorders and assisted reproductive technologies
Aberrant expression of imprinted genes results in imprinting disorders (IDs). Differentially methylated regions (DMRs) reveal parental-origin-specific DNA methylation on CpGs and regulate the expression of the imprinted genes. One etiology of IDs is epimutation (epi-IDs) …
Read PDFMultimodal artificial intelligence in urologic precision oncology: from algorithm to translational medicine (a systemized narrative review)
Precision oncology in urology increasingly depends on integrating heterogeneous data, including multiparametric imaging, histopathology, genomics, and clinical variables. Multimodal artificial intelligence (AI) offers a unified framework to manage this complexity, supporting refined risk stratification, personalized …
Read PDFSemantic alignment of the German Human Genome-Phenome Archive metadata model in Europe's genomics field
Legal and technical developments drive data sharing via federated infrastructures, especially in the field of human omics. This requires interoperability across technical, syntactic, organizational, and semantic layers. The German Human Genome-Phenome Archive (GHGA) has been …
Read PDFSingle-cell multi-omics in biliary tract cancers: decoding heterogeneity, microenvironment, and treatment strategies
Biliary tract cancer (BTC) is a highly heterogeneous and aggressive gastrointestinal malignancy, marked by a high mortality rate and limited treatment efficacy. The primary contributing factors include the absence of reliable early detection methods, the …
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