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Polyamines (PAs) play critical roles in plant growth, somatic embryogenesis (SE), etc. Previous studies have demonstrated that exogenous PAs could promote SE in plants. However, the effects of PAs on <i>Ginkgo biloba</i> L. SE are …
Read PDFUnderstanding transcriptional regulatory networks (TRNs) in microglia is essential for elucidating mechanisms underlying central nervous system (CNS) disorders. Human induced pluripotent stem cell (iPSC)-derived models enable mechanistic studies of microglia but often suffer from variability …
Read PDFDeferiprone (DFP) is an iron chelator approved for treating iron overload in thalassemia patients. Recent observations have suggested that DFP has promising anticancer activities ascribed to several mechanisms, including reduction of the intracellular free labile …
Read PDFThere are a bewildering number of variables to consider when planning an RNA sequencing study (RNA-Seq). Here we discuss some of the considerations for an investigator initiating such studies, with a focus on library preparation, …
Read PDF<h4>Background</h4>Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties.<h4>Methods</h4>The activity of BCV was evaluated in 44 cell-line models, including T/NK-cell non-Hodgkin lymphoma (T/NK-NHL, n = 25) and B-cell lymphoma …
Read PDFBees are important pollinators that are increasingly threatened by viruses. In this study, we investigated the viruses in honey bees in Bangladesh, focusing on western (<i>Apis mellifera</i>) and native bee species (<i>A. cerana</i>, <i>A. dorsata</i>, …
Read PDF<h4>Introduction</h4>While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored.<h4>Methods</h4>We conducted a comprehensive analysis of RNA editing across nine human brain …
Read PDFFacioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disease in which genetic mutations activate DUX4 expression in skeletal muscle. Currently, there are no approved therapies for FSHD. We developed Delpacibart braxlosiran (del-brax, also known …
Read PDFSweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ-specific control. We hypothesised that phenotypic variation …
Read PDFEquine herpesvirus type 1 (EHV-1) is a high morbidity and mortality virus that impacts horse populations worldwide. As a respiratory virus, it enters through the upper respiratory tract (URT), where mucosal immunity plays a crucial …
Read PDF<b>Background/Objectives</b>: Combinations of PARP inhibitors (PARPi) and androgen receptor pathway inhibitors (ARPi) have led to clinical success in treating advanced prostate cancer. However, it is unclear where in the clinical paradigm these combinations will fare …
Read PDFColibacillosis caused by Avian Pathogenic Escherichia coli (APEC) is a major threat to poultry, and yolk sac infection is a leading cause of embryonic mortality. However, the molecular mechanisms and host responses during the infection …
Read PDFThe polarization of naive CD4+ T cells into Th2 cells is initiated in lymphoid organs and completed as the cells become tissue resident, where they express ST2, the receptor for the alarmin interleukin (IL)-33, which …
Read PDFB cell receptor (BCR) signaling is required for the regulation of normal B lymphocyte development. However, many B cell lymphoma subtypes employ constitutive BCR signaling for transformation, survival, and growth. Here we report that mice …
Read PDFCancer progression involves extensive alterations in epigenetic and gene expression programs, but the accompanying changes in higher-order genome organization remain less well understood. Using high-resolution Micro-C mapping in the MCF10 cell model of breast cancer, …
Read PDFFlower color is a key ornamental trait in Nobile-type <i>Dendrobium</i>, yet the molecular basis underlying purple flower formation remains poorly understood. In this study, a white-flowered paternal cultivar and its purple-flowered filial line were used …
Read PDFGenome-wide association studies (GWASs) have identified many sources of genetic variation associated with bone mineral density (BMD), a clinical predictor of fracture risk and osteoporosis. Aside from the identification of causal genes, other difficult challenges …
Read PDF<h4>Background</h4>We investigate the flow of genetic information from DNA to RNA to protein as described by the Central Dogma in molecular biology, to determine the impact of intermediate genomic levels on plant protein expression.<h4>Results</h4>We perform …
Read PDFThe amount of soluble inorganic phosphate (Pi) in soils is typically low and limiting plant growth. Roots of trees in several forest ecosystems form association with ectomycorrhizal (ECM) fungi, where fungi forage and supply inorganic …
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