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Depression frequently cooccurs with epilepsy (EP) and has become a focus of clinical management, but effective pharmacological interventions remain limited. In this study, single-cell RNA sequencing (scRNA-seq) data were analyzed to identify changes in oligodendrocyte …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) is an aggressive cancer with limited therapies. Although transposable element-derived genes are increasingly linked to tumorigenesis, the role of the TIGD family in HCC remains unclear. This study examined the expression, clinical …
Read PDF<h4>Background</h4>Monocyte-derived macrophages (MoMFs) play key roles in liver inflammation and fibrogenesis, with their heterogeneity affecting metabolic dysfunction-associated steatotic liver disease (MASLD) progression. However, current therapeutic strategies targeting macrophage-mediated inflammation have shown limited clinical efficacy in …
Read PDFThe high mortality rate of metastatic cutaneous melanoma (SKCM) remains a major challenge in clinical treatment. This study used single-cell RNA sequencing (scRNA-Seq) technology to compare the differences between metastatic and primary tumour cells. By …
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Read PDFAging is a regulated process marked by the accumulation of senescent cells, which remain viable but no longer divide. Senescent cells contribute to age-associated phenotypes and diseases, including osteoarthritis, dementia, and cancer, but their scarcity …
Read PDFBACKGROUND: Single-cell technologies allow detailed mapping of cell type-specific regulatory and transcriptomic landscapes, yet a systematic way to quantify cell type specificity of chromatin accessibility and gene expression remains limited. SPICEY (SPecificity Index for Coding …
Read PDFReconstructing causality routes from genetic effects to complex phenotypes in particular cell types is crucial for understanding biological mechanisms underlying the brain-associated phenotypes including imaging-derived phenotypes (IDPs), and brain disorders and behaviors (DBs). Here, we …
Read PDFGastrointestinal cancer is one of the most burdensome health threats worldwide, accounting for approximately one-quarter of all cancer incidences. Gastric and colorectal cancers are among the most prevalent and lethal malignancies of the gastrointestinal tract …
Read PDFImmune checkpoint inhibitors (ICIs) have transformed the advanced melanoma treatment landscape; however, a subset of patients achieve durable responses. Current biomarkers, such as PD-L1 expression and tumor mutational burden, offer limited predictive power due to …
Read PDF<h4>Background</h4>Ulcerative colitis (UC) is a chronic, multifactorial inflammatory bowel disease. The involvement of small GTPase-related genes (SGRGs) in UC remains poorly defined. This study aims to identify SGRGs associated with UC and elucidate the molecular …
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Read PDFSevere fever with thrombocytopenia syndrome (SFTS), caused by <i>Dabie bandavirus</i> (DBV), triggers aberrant immune activation and cytokine storms, contributing to poor prognosis; however, its immune dysfunction mechanism remains unclear. Current management relies on symptomatic treatment …
Read PDF<h4>Background</h4>Cancer cachexia leads to decreases in body mass, lean mass and fat mass, decreased therapeutic potential and ~20% of cancer-related deaths. While several studies have demonstrated changes to components of the muscle microenvironment with cancer …
Read PDFCraniosynostosis is a common defect in the craniofacial structure of children, yet its pathogenesis remains unclear. Current research focuses mainly on bone-related genetic mutations, with less emphasis on lipid metabolism disorders. Hence, it is imperative …
Read PDFLive single-cell metabolomics is a rapidly growing area of research, which offers the potential to provide unique insights into cellular function and heterogeneity. Single-cell isolation approaches based on capillary sampling are in principle compatible with …
Read PDF<b>Purpose:</b> Data stability is a critical factor in Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) single-cell analysis. However, various factors, such as sample processing, instrument condition, and data acquisition, can introduce uncertainties into ToF-SIMS data. Correcting …
Read PDF<h4>Background</h4>Endometriosis (EM) is associated with immune dysregulation, while dysfunction of natural killer (NK) cells is regarded as a key mechanism underlying immune escape and the persistent growth of ectopic lesions.<h4>Method</h4>This study used single-cell RNA sequencing …
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