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RNA methylation, particularly N6-methyladenosine (m<sup>6</sup>A) and 5-methylcytosine (m<sup>5</sup>C), functions as a pivotal post-transcriptional regulatory mechanism and plays a central role in plant growth, development, and stress responses. This review provides a systematic summary of recent …
Read PDFThere is no immunohistochemical or molecular marker to confirm the histologic diagnosis of pancreatic ductal adenocarcinoma (PDAC). This is particularly important in a scenario of unknown primary. Molecularly, PDAC is characterized by a limited set …
Read PDFMethylomics has emerged as a central framework for understanding gene regulation in development and disease, yet the rapid expansion of profiling technologies, computational integration methods, and clinical applications has outpaced comprehensive synthesis. This review addresses …
Read PDFDNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure. The identification of sites with high methylation variability can be …
Read PDFThe mammalian circadian clock is an autoregulatory feedback process that is responsible for homeostasis in mouse livers. These circadian processes are well understood at the gene level; however, they are not well understood at the …
Read PDFRiccia sorocarpa Bisch., commonly known as common crystalwort, is a plant belonging to the Marchantiales order with a cosmopolitan distribution among a wide range of habitats: fields, gardens, waste ground, on paths, cliff tops, and …
Read PDFPhlomoides rotata (Duyiwei), a threatened Tibetan medicinal plant with anti-inflammatory and analgesic properties, has an understudied genome. We generated a chromosome-level assembly of its 4.12 Gb genome using Oxford Nanopore, PacBio HiFi, Illumina, and Hi-C …
Read PDFMalaria, a tropical disease caused by Plasmodium and transmitted by Anopheles, remains a public health concern in Brazil. While most cases occur in the Amazon, transmission persists in the Atlantic Forest, where Anopheles mosquitoes of …
Read PDFReference genomes are key resources in biodiversity conservation. Yet, sequencing efforts are not evenly distributed across the tree of life raising concerns over our ability to enlighten conservation with genomic data. Good-quality reference genomes remain …
Read PDFWe determined that the dengue outbreak in São Tomé and Príncipe during 2022 was caused by dengue virus serotype 3 genotype III. Phylogenomic analyses showed that the outbreak strain was closely related to the newly …
Read PDFThe red-legged partridge ( <i>Alectoris rufa</i>) is a socio-economically important game bird in southern Europe. Despite previous efforts, achieving a high-quality, chromosome-level genome assembly has remained challenging. Here, we present a <i>de novo</i> phased, gapless …
Read PDF<b>Introduction</b>: In recent years, antimicrobial resistance (AMR) rates have increased significantly in bacterial pathogens, particularly extended beta-lactam resistance. This study aimed to investigate resistome and phylogenomics of <i>Escherichia coli</i> (<i>E. coli</i>) strains isolated from various …
Read PDFCoronaviruses rapidly evolve and are prone to new virus emergence. Human coronavirus (HCoV)-229E is one of the seven coronaviruses (aside HCoV-OC43, HCoV-HKU1, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) causing respiratory infections in humans. Genomic data are very …
Read PDF<i>Phytophthoracryptogea</i> Pethybr. & Laff. and <i>P.erythroseptica</i> Pethybr. are oomycetes that cause root rot diseases of multiple plant species, including serious diseases of potato. These two species of <i>Phytophthora</i> were originally reported in Ireland more than …
Read PDFHere, we present a dataset of ITS and β-tubulin sequences, along with a phylogenetic analysis using these molecular markers, for six putative <i>Fusarium</i> strains isolated from blackberry field soil. Additionally, we report the sequencing and …
Read PDF<h4>Background</h4>Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contraction of the D4Z4 repeat on chromosome 4q35, …
Read PDFAntimalarial drug resistance has become a real public health problem despite WHO measures. New sequencing technologies make it possible to investigate genomic variations associated with resistant phenotypes at the genome-wide scale. Based on the use …
Read PDFFollicle selection is an important step in the laying process of chicken, which is closely related to the laying performance and fecundity of hens. Follicle selection mainly depends on the regulation of follicle-stimulating hormone (FSH) …
Read PDFDespite the successful identification of causative genes and genetic variants of retinitis pigmentosa (RP), many patients have not been molecularly diagnosed. Our recent study using targeted short-read sequencing showed that the proportion of carriers of …
Read PDFHuntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG trinucleotide repeat expansions in exon-1 of <i>huntingtin</i> (<i>HTT</i>). Currently, there is no cure for HD, and the clinical care of individuals with HD …
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