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Regulation of Mitophagy by Low-Intensity Pulsed Ultrasound Attenuates Endothelial Dysfunction
<b>Background</b>: Diabetic vascular complications are a major cause of poor prognosis in patients with diabetes mellitus (DM). Mitophagy activation is a potential therapeutic target for type 2 diabetes mellitus (T2DM), but the role of low-intensity …
Read PDFSafety and efficacy of a feed additive consisting of l-histidine monohydrochloride monohydrate produced with <i>Escherichia coli</i>CCTCC M 20241089 for all animal species (Anhui Huaheng Biotechnology Co., Ltd)
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-histidine monohydrochloride monohydrate produced with a genetically modified strain of <i>Escherichia coli</i> (CCTCC M …
Read PDFDecoding the antihypertensive mechanism of cannabidiol through integrative bioinformatics and machine learning
BACKGROUND: Hypertension (HTN) results from intricate molecular mechanisms, making clinical remission difficult to achieve. This study explores the molecular pathways through which cannabidiol (CBD) may influence HTN. METHODS: Several RNA sequencing datasets related to HTN …
Read PDFMultimodal learning on heterogeneous subgraphs and LLMs representation for MHC-peptide binding affinity prediction
Accurate prediction of MHC-peptide binding affinity remains a challenge for immunotherapeutic development. Existing methods struggle to jointly model functional semantics of polymorphic residues, evolutionary conservation constraints, and structural dynamic. We propose the Contrast learning-based Multi-feature …
Read PDFCausal association and molecular mechanisms of periodontal disease and muscle wasting and atrophy: Mendelian randomization and bioinformatics analysis
<h4>Background</h4>Periodontal disease, a chronic inflammatory disorder, is increasingly linked to systemic conditions. This study investigates its causal role in muscle wasting via chronic inflammation, aiming to inform integrative therapeutic strategies.<h4>Methods</h4>Mendelian randomization (MR) analysis was applied …
Read PDFUncovering environmental pollutants affecting Atlantic cod growth with machine learning
No abstract available.
Read PDFRETRACTION: Integrated Bioinformatics-Based Identification of Potential Diagnostic Biomarkers Associated with Diabetic Foot Ulcer Development
[This retracts the article DOI: 10.1155/2021/5445349.].
Read PDFComprehensive analysis of the chloroplast genome structure and phylogeny of <i>Glochidion puberum</i> (L.) Hutch
<i>Glochidion puberum</i> (L.) Hutch., a member of the family Phyllanthaceae, is widely distributed in China and possesses both medicinal and ornamental value. Despite its ecological and economic significance, the complete chloroplast genome of <i>G. puberum</i> …
Read PDFWhole-genome sequences of two novel chitinolytic bacterial strains within the genera <i>Streptomyces</i> and <i>Pseudomonas</i>
<i>Streptomyces</i> sp. CLCI03 and <i>Pseudomonas</i> sp. CLCA07 were isolated from soil suspensions cultured on chitin-amended Winogradsky medium. Whole-genome analyses of these two strains revealed genome sizes of 8.68 and 6.73 Mb with G + C …
Read PDFMIRit: an integrative R framework for the identification of impaired miRNA-mRNA regulatory networks in complex diseases
<h4>Motivation</h4>MicroRNAs (miRNAs) play a central role in controlling gene expression, and their abnormal activity is frequently linked to disease. Despite advancements in transcriptomic technologies, elucidating miRNA-mediated mechanisms remains challenging due to methodological limitations and a …
Read PDFArtificial intelligence for antimicrobial resistance: advancing reproducibility, interpretability, and clinical deployment
The shift of artificial intelligence for antimicrobial resistance (AI-AMR) from proof-of-concept studies to clinically embedded decision support critically hinges on establishing rigorous reproducibility, interpretability, and evaluation standards aligned with antimicrobial stewardship and patient safety. This …
Read PDFUnlocking therapeutic impacts of the gut microbiota with computational tools
The human gut microbiota, particularly the intestinal microbiota, shapes host physiology, disease risk, and therapeutic outcomes through complex metabolic and enzymatic activities. Recent advances in molecular omics, metabolomics, enzyme bioinformatics, and artificial intelligence (AI) have …
Read PDFEvaluation of PD-L1 Expression and Systemic Inflammatory Blood Cell Ratios as Prognosticators in Advanced Lung, Breast and Head and Neck Cancers
<h4>Introduction</h4>Immunotherapy with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis has become an established treatment strategy across various malignancies. In this context, PD-L1 expression plays a key role in the clinical management of cancer patients. …
Read PDFTarget and biomarker exploration portal for drug discovery
<h4>Motivation</h4>The discovery of novel drug targets and precision biomarkers remains a major challenge in drug development, with traditional differential expression analysis often overlooking key regulatory proteins. Here, we present a novel, web-based bioinformatics tool, the …
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