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BACKGROUND: Small nucleolar RNAs (snoRNAs) are increasingly recognized for their involvement in human diseases. Accurate and robust prediction of disease-associated snoRNAs is crucial for accelerating drug discovery and disease treatment. However, the limited availability of …
Read PDFParkinson's disease (PD) is a complex neurodegenerative disorder for which current treatments are often symptomatic and lack disease-modifying effects. The traditional Chinese medicine herb pair Tianma-Gouteng, composed of <i>Gastrodia elata</i> Bl (Tianma) and <i>Uncaria rhynchophylla</i>(Miq.) …
Read PDF<h4>Background</h4>The incidence of papillary thyroid cancer (PTC) has risen sharply over the past several decades. Early identification of high-risk PTC is crucial to mitigate the societal burden associated with its overdiagnosis. ER-phagy, a selective form …
Read PDF<h4>Background</h4>Regulated cell death (RCD) maintains cellular homeostasis and tissue integrity, playing a pivotal role in both health and disease. A variety of RCD subroutines have been identified, each characterized by distinct molecular and morphological features. …
Read PDFGMrepo (Gut Microbiome Data Repository) is a curated and consistently annotated database of human gut metagenomes, designed to improve data reusability and enable cross-project and cross-disease comparisons. In this latest release, GMrepo v3 has been …
Read PDFBACKGROUND: N6-methyladenosine ([Formula: see text]) plays a crucial role in enriching RNA functional and genetic information. While deep learning has advanced [Formula: see text] site identification, current state-of-the-art methods, particularly those based on large-scale Pre-trained …
Read PDF<h4>Motivation</h4>High-dimensional sequencing data, such as RNA-Seq for gene expression and ATAC-Seq for chromatin accessibility, are widely used in studying systems biology. Accessible chromatin allows transcription factors and regulatory elements to bind to DNA, thereby regulating …
Read PDFThe present study aims to identify key genes and elucidate the molecular mechanisms underlying osteonecrosis of the femoral head (ONFH), with the goal of discovering effective diagnostic and therapeutic targets. Microarray data were sourced from …
Read PDFThe rise of mRNA vaccines highlights the pivotal role of T-cell antigen identification in modern vaccinology and personalized medicine. T-cell recognition relies on the sophisticated ternary interaction between the T-cell receptor (TCR), the major histocompatibility …
Read PDFBACKGROUND: Diabetic nephropathy (DN) has been pathophysiologically associated with macrophage activity; however, the molecular mechanisms underlying this relationship remain unclear. This study aimed to explore the regulatory mechanisms linking DN and macrophages using integrated bioinformatics …
Read PDFCopy number variants (CNVs) have been shown to play a significant role in the pathogenesis of various human diseases. Although several tools have been developed for detecting CNVs based on whole-exome sequencing (WES) data, their …
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Read PDF<h4>Ethnopharmacological relevance</h4><i>Fritillariae Cirrhosae Bulbus</i> is a traditional herb with diverse activities, yet its active metabolites against type 2 diabetes (T2D) remain unclear.<h4>Objective</h4>This study aimed to identify key bioactive metabolites from <i>Fritillariae Cirrhosae Bulbus</i> through database …
Read PDF<h4>Background</h4>Lumbrokinase is a novel antithrombotic drug isolated and purified from earthworms and used in the treatment of stroke and cardiovascular disease. However, to date, there has been no systematic classification of lumbrokinase genes.<h4>Methods</h4>In this study, …
Read PDFBACKGROUND: Single-cell RNA sequencing (scRNA-seq) is considered a revolution in gene expression studies and offers significant benefits across various fields of biomedical or clinical applications. However, a high proportion of technical dropouts in scRNA-seq data …
Read PDF<h4>Summary</h4>Lipid-protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has long been hindered by the inherent biochemical properties of lipids. Recent advances in functionalized lipid probes-equipped with photoactivatable crosslinkers, …
Read PDF<h4>Objective</h4>This study, utilising bibliometric analysis combined with bioinformatics approaches, systematically analysed research trends in the fields of osteoporosis (OP) and autophagy (ATG) over the past two decades, with a focus on the emerging frontier of …
Read PDFColorectal cancer (CRC) is a significant global health challenge, closely linked with inflammatory bowel disease (IBD). Understanding the genetic and molecular underpinnings of CRC and its association with IBD is critical for early diagnosis and …
Read PDFParaquat, a highly toxic herbicide, frequently causes acute poisoning, predominantly inducing pulmonary injury and fibrosis with high mortality, and no specific antidote is available. This study aimed to explore its pathogenesis using a paraquat-induced mouse …
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