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Hepatocellular carcinoma (HCC) is a highly malignant tumour with a poor prognosis and few effective treatment options. Development of resistance to conventional therapies and occurrence of severe side effects highlight the urgent need for novel, …
Read PDF[This corrects the article DOI: 10.21037/jtd-23-1822.].
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Read PDF<h4>Background</h4>Sanjie Xiaoliu Granule (SJXLG), a traditional multi-herbal prescription widely used in Chinese medicine, has been historically applied to "disperse nodules, soothe the liver, and relieve depression." It is clinically prescribed for patients with breast lumps, …
Read PDFAccurate detection of all types of mitochondrial DNA (mtDNA) variants, including single large-scale mtDNA deletions (SLSMDs) and multiple mtDNA deletions (MMDs), along with heteroplasmy quantification, is essential for Primary Mitochondrial Disease (PMD) diagnosis. This study …
Read PDFAtherosclerosis (AS) is a chronic inflammatory vascular disorder in which endoplasmic reticulum stress (ERS) plays a crucial regulatory role. However, the biological and translational relevance of ERS-related gene networks in AS remains largely unexplored. This …
Read PDF<h4>Motivation</h4>High-throughput extraction and structured labeling of data from academic articles are crucial for enabling downstream machine learning applications and secondary analyses. Current approaches lack integration with the publishing process and comprehensive annotation of experimental roles …
Read PDFBACKGROUND: Predicting the binding affinity between drugs and proteins is crucial for accelerating drug discovery. However, traditional research methods typically treat binding site detection and affinity prediction as two separate tasks, lacking solutions that integrate …
Read PDFThis study aimed to identify tumor-associated autoantibodies (TAAbs) with diagnostic potential for the early detection of oral squamous cell carcinoma (OSCC). Bioinformatics analyses were used to screen candidate genes. The candidate tumor-associated antigens (TAAs) were …
Read PDFBreast carcinoma ranks among the most prevalent malignant tumors affecting women worldwide. The discovery of biomarkers is important in the diagnosis of breast cancer and the prediction of clinical outcomes in afflicted patients. Heterogeneous nuclear …
Read PDF<h4>Background</h4>An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC). The systematic review aimed to summarize the characteristics of ferroptosis from its pathogenetic …
Read PDF<h4>Motivation</h4>Illumina DNA methylation arrays have evolved rapidly, expanding genomic coverage while introducing backward incompatibilities by removing many CpG sites present in earlier versions. These changes result in systematic missing values when integrating data across array …
Read PDF<h4>Motivation</h4>Antibiotic resistance is predicted to become the leading cause of human mortality by 2050. Despite this, no other major antibiotic class has been approved for medical use since 1987. Nevertheless, phage tail proteins offer a …
Read PDF<h4>Motivation</h4>Sequence motif identification is crucial for understanding molecular recognition, particularly in immune responses involving peptide binding to major histocompatibility complex (MHC) Class I molecules for antigen presentation to T cells. Traditionally, MHC Class I binding …
Read PDFStenotrophomonas spp. are increasingly recognized as opportunistic pathogens with high levels of antimicrobial resistance (AMR). Despite their clinical importance, genomic diversity within the genus remains underexplored, particularly in Thailand and Southeast Asia. Ten Stenotrophomonas strains …
Read PDF<h4>Introduction</h4>Obesity and non-alcoholic fatty liver disease (NAFLD) are known to be closely interlinked; however, the mechanism of their interaction is unclear. This study sought to explore the causal relationship and shared biomarkers in obesity and …
Read PDFWe present CBR-db, a database with detailed chemical properties data for biochemical compounds and reactions. We provide the first chemically consistent analyses and detailed chemical property data for a biologically relevant set of 148,673 reactions …
Read PDF<h4>Background</h4>Infected bone defects are difficult to treat due to bacterial biofilms and chronic inflammation. Systemic antibiotics often fail and cause severe side effects. A dual-drug delivery system that combines antibacterial and osteo-immunomodulatory actions may offer …
Read PDFBreast cancer is a prevalent malignancy among women worldwide. Understanding its molecular mechanisms is crucial for prevention, early diagnosis, and treatment. Using a dataset of intraoperative radiotherapy (IORT) for breast cancer, we analyzed 21 breast …
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