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The HUGO Clinical Genomics & Genomic Medicine Education Survey: clinicians globally need and want genomic medicine training
BACKGROUND: The Clinical Genomics & Genomic Medicine Education subcommittee of the Human Genome Organization (HUGO) reports on the results of an exploratory genomic medicine survey of healthcare providers (clinicians) in low- and middle-income countries. RESULTS: …
Read PDFDraft genome sequence of <i>Streptococcus gallolyticus</i> AAM02 isolated from traditional fermented milk in Bangladesh
We announce the draft genome sequence of <i>Streptococcus gallolyticus</i> strain AAM02, isolated from traditional fermented milk (doi) collected in Bogura, Bangladesh (GPS: 24.85°N, 89.37°E) in 2023. The genome provides insights into its genetic adaptations to …
Read PDFComplete mitochondrial genome of <i>Aphlugiolopsis trapeziformis</i> (Orthoptera: Tettigoniidae: Meconematinae)
In this study, we determined and analyzed the complete mitochondrial genome of <i>Aphlugiolopsis trapeziformis</i>. The mitogenome of <i>A. trapeziformis</i> (length: 16,766 bp) is double-stranded circular. It contains the 37 typical mitochondrial genes (13 protein genes, …
Read PDFGenome Variation Map: a platform for the analysis and integration of genomic variation
The Genome Variation Map (GVM; https://ngdc.cncb.ac.cn/gvm) serves as a public repository for genetic variation data. This version represents a major upgrade to GVM, integrating rigorously curated high-quality DNA resequencing data from a wide range of …
Read PDFCharcoal rot in sesame: infection biology, host resistance mechanism, and genomic-enabled strategies for durable resistance breeding
Sesame (Sesamum indicum L.) is a globally important oilseed crop, but its production is constrained by charcoal rot, caused by the soil-borne fungus Macrophomina phaseolina. The pathogen's exceptionally broad host range, long-term soil persistence through …
Read PDFReference Genome Assembly of a Tetraploid Accession of the Tuber Crop Tropaeolum tuberosum
Tropaeolum tuberosum is a tuber-forming crop native to the Andes, valued for its nutritional content, pest resistance, and adaptation to high-altitude environments. Despite its contribution to food security and sustainable agriculture, it remains an underutilized …
Read PDFArtificial intelligence and genomic data privacy: Balancing innovation with security
No abstract available.
Read PDFEpidemiological investigation of an acute gastroenteritis outbreak associated with norovirus GΙΙ.17[P17] in a cross-border travel group - Shanghai Port, China, 2024
<h4>Background</h4>Norovirus is a leading cause of acute gastroenteritis and spreads efficiently in closed, mobile cohorts such as organized travel groups. This case is notable for the real-time detection and genomic confirmation of a cross-border outbreak …
Read PDFIntegrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle
Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative …
Read PDFDraft genome sequence of <i>Enterobacter</i> sp. I4, an endophytic bacterium isolated from <i>Aloe barbadensis</i> Miller
We report the draft genome sequence of <i>Enterobacter</i> sp. strain I4, an endophytic bacterium isolated from healthy <i>Aloe barbadensis</i> Miller leaves and stems. The 4.7-Mb genome (56.5% GC) comprises three contigs and encodes 4,339 predicted …
Read PDFIntegrated multi-omics profiling unveils a network of key signaling pathways governing ovarian function and systemic regulation in high-prolificacy goats
<h4>Background</h4>Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified several candidate genes, a comprehensive understanding of the …
Read PDFGenerative models of cell dynamics: from Neural ODEs to flow matching
Neural Ordinary Differential Equations (Neural ODEs) have emerged as a prominent framework for modeling complex dynamical systems. Their ability to describe a system's underlying dynamical law has attracted attention to applications in life sciences. Single-cell …
Read PDFNew transcription signals in SARS-CoV-2 reshape virus-host interactions
Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses.
Read PDFBurden of heterozygote carriers for autosomal recessive conditions in the Middle East: A study of 14,392 genomes
The American College of Medical Genetics and Genomics (ACMG) recommends Tier-3 reproductive carrier screening for 97 genes associated with autosomal recessive (AR) conditions (AR genes). Gene selection for screening is based on a gene carrier …
Read PDFMulti-omics analysis reveals the response mechanism of Pichia kudriavzevii to high-concentration lactic acid stress
Pichia kudriavzevii tolerance mechanisms are not well understood, even though strong-flavor Baijiu fermentation places a heavy burden on yeast metabolism due to the accumulation of lactic acid (LA). This study utilized growth kinetics, electron mi-croscopy, …
Read PDFHow do RNA molecules distinguish self from non-self?
RNA molecules form homotypic clusters in a variety of contexts. mRNAs enriched in germ granules in <i>Drosophila</i> embryos are a canonical example, with <i>polar granule component</i> (<i>pgc</i>) mRNAs colocalized with other <i>pgc</i> mRNAs, and <i>nanos</i> …
Read PDFShared genetic architecture between Alzheimer's disease and psychiatric disorders revealed by multi-trait genome-wide analyses
OBJECTIVE: Clarify the shared genetic architecture between Alzheimer’s disease (AD) and major psychiatric disorders. METHODS: We integrated large GWAS summary datasets derived predominantly from individuals of European ancestry for AD and eight psychiatric disorders; estimated …
Read PDFProthrombin G20210A and Factor V Leiden Variants Are Not Associated With Thrombotic Events in Congenital Heart Disease: An Observational Trial
<h4>Background</h4>Thrombotic events, including acute ischemic stroke, are more common in individuals with congenital heart disease (CHD). Whether common thrombophilia variants contribute to thrombotic risk in this population remains unclear. We evaluated whether prothrombin G20210A (<i>F2</i> …
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