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Donkeys (<i>Equus asinus</i>) are economically and ecologically important livestock species whose genetic potential remains underexplored. This review synthesizes recent advances in donkey genomics, tracing their evolutionary history while evaluating current applications in selective breeding, conservation …
Read PDFWe thank Dr. George Sangster and Dr. Jolanda A. Luksenburg for their careful assessment concerning the mitochondrial genome sequence of <i>Haliastur indus</i> (GenBank accession number: OP133375.1) [...].
Read PDFThe fresh-market blackberry (Rubus subgenus Rubus) industry has expanded dramatically in the past 2 decades, driven in part by improved cultivars. Introgression of the primocane-fruiting (PF; annual flowering) trait into elite germplasm has enabled dual …
Read PDF<h4>Background</h4>Altered lipid metabolism is increasingly recognized as a driver of tumor progression, yet its specific role in thyroid cancer remains unclear.<h4>Methods</h4>We combined Mendelian randomization with transcriptomic and single-cell analyses to identify lipid-related factors that contribute …
Read PDFEvolution reflects a balance between innovation and constraint, often repurposing existing components in new contexts. Convergent evolution exemplifies this interplay, with similar traits evolving independently in different species, yet the genomic mechanisms enabling this repeatability …
Read PDF<h4>Background</h4>Pediatric cough-variant asthma is characterized by chronic airway inflammation and epithelial dysfunction driven by complex cellular interactions and molecular regulatory networks. Understanding the cellular heterogeneity and molecular mechanisms underlying pediatric asthma pathogenesis remains challenging. Single-cell …
Read PDFBACKGROUND: Aedes triseriatus is an endemic North American mosquito and the primary vector of La Crosse virus, the etiologic agent of La Crosse encephalitis. This neuroinvasive disease is the leading cause of arboviral encephalitis in …
Read PDF<h4>Introduction</h4>Newborn bloodspot screening (NBS) is freely and universally available to babies born in Australia, with nearly 300 000 newborns screened each year. The NBS programme screens for approximately 30 conditions; however, there are hundreds of …
Read PDF<b>Background.</b> <i>Salmonella enterica</i> serovar Typhi (<i>S</i>. Typhi), the causative agent of typhoid fever, continues to pose a major public health challenge in many low- and middle-income countries. The World Health Organization recommended typhoid conjugate vaccine …
Read PDFHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, and transcatheter arterial chemoembolization (TACE) remains the core locoregional therapeutic modality for patients with intermediate to advanced disease. However, a considerable proportion …
Read PDFCongenital disorders of glycosylation (CDGs) are a phenotypically diverse group of genetic conditions arising from pathogenic variants in various glycosylation pathways. The most prevalent are N-glycosylation disorders. Here, we present clinical and biochemical data on …
Read PDFBACKGROUND: Genetic nephrology has emerged as a distinct subspecialty within nephrology with growing evidence supporting its clinical utility and cost-effectiveness across diagnostic, prognostic, and management pathways. Yet significant implementation gaps such as undefined clinic models …
Read PDFCotton improvement remains a major challenge in plant biotechnology because stable yield, fiber quality, and stress resilience must be delivered from complex allopolyploid genomes under variable environmental conditions. Genetic mapping has progressively transformed this challenge …
Read PDFThe Triticeae tribe, encompassing staple crops like bread wheat (Triticum aestivum), barley (Hordeum vulgare), and rye (Secale cereale), underpins global food security due to its agronomic importance and genetic diversity. While RNA-seq has revolutionized transcriptome …
Read PDF<i>Brucella abortus</i> is a globally significant zoonotic pathogen. To explore the functional relevance of its genes in acidic, oxidative, and antimicrobial stress conditions, we constructed high-density transposon sequencing libraries in the attenuated <i>B. abortus</i> S19 …
Read PDFSmoking is a major modifiable risk factor for myocardial infarction (MI); however, the molecular mechanisms through which its core component nicotine and its primary metabolite cotinine mediate MI development remain incompletely understood. This study aimed …
Read PDFBACKGROUND: A highly complex karyotype (high-CK) is a key biomarker of poor prognosis in chronic lymphocytic leukemia (CLL). While conventional methods lack the resolution to fully characterize complex structural variants (SVs), emerging technologies such as …
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