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Fli1b is an ETS transcription factor, which has been previously implicated in zebrafish vascular and hematopoietic development. Here we present single cell RNA sequencing data from wild-type and maternal zygotic <i>fli1b</i> mutant zebrafish embryos at …
Read PDF<h4>Introduction</h4>Thalassemia, the most prevalent recessive genetic disorder in China, predominantly affects the southern coastal regions. The mutational spectrum of α-thalassemia (α-thal) continues to expand with advances in detection technologies.<h4>Methods</h4>Fetal DNA was extracted from amniotic fluid …
Read PDFBACKGROUND: The lack of reliable screening biomarkers for prostate cancer (PC) diagnosis makes tissue biopsy the gold-standard strategy. However, its frequent inconclusive results often lead to repeated procedures, increasing patient burden and healthcare costs. In …
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Read PDFPrimary ciliary dyskinesia (PCD) is a rare multi-system cilia-related disorder, and approximately 50% of individuals with PCD exhibit left-right asymmetry disorder. The dynein axonemal heavy chain 11 gene (DNAH11) pathogenic variants are responsible for primary …
Read PDFDespite the epidemiological importance of triatomine bugs as vectors of Trypanosoma cruzi, mitogenomic resources remain limited for many lineages, restricting evolutionary and comparative analyses. The endemic Chilean genus Mepraia is a notable example, with scarce …
Read PDF<h4>Background</h4>Selective breeding has substantially improved productive and reproductive traits in pigs. Yet, these traits are biologically interconnected, and selection for one often affects others in unintended ways. While genome-wide association studies (GWAS) have uncovered many …
Read PDFGenetic variation in ATP Binding Cassette Subfamily C Member 6 (ABCC6) can cause both pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI). There are 930 distinct missense variants in ABCC6 reported, 87% of …
Read PDF<h4>Background/aim</h4>Hepatocellular carcinoma (HCC) exhibits substantial metabolic plasticity that supports tumor progression and therapeutic resistance. LGALS3BP has been primarily characterized as a secreted immunomodulatory protein; however, its cell-intrinsic role in regulating subcellular organization and metabolism in …
Read PDFBACKGROUND: As an important economic trait in ducks, residual feed intake (RFI) may be influenced by the intestinal microbiota. However, the mechanisms underlying microbiota-host crosstalk remain unclear. RESULTS: We analyzed the total egg number (TEN), …
Read PDFOral health disparities are closely linked to broader health inequalities, particularly in global health contexts where disproportionate emphasis is placed on diseases other than oral health. In the field of dental genetics, recent investigations have …
Read PDF<h4>Background</h4>Virus mutants are commonly used for studying the role of individual viral proteins in infections and are increasingly investigated with functional genomics experiments of infected cells that use sequencing-based assays such as RNA-seq or ATAC-seq. …
Read PDFBougainvillea (Bougainvillea spp.) is an important ornamental shrub, yet its cultivar identification and genetic background remain poorly characterized. To address this, we developed 18 polymorphic SSR markers based on the B. glabra ‘Formosa’ genome and …
Read PDF<h4>Background</h4>Multimorbidity, also known as multiple long-term conditions, is a major public health concern. Internalising and CardioMetabolic MultiMorbidity (ICM-MM) is a common form of mental-physical health multimorbidity, yet its genetic predisposition is largely unknown. We examined …
Read PDFBACKGROUND: Sanghuangporus species are white-rot basidiomycetes of notable ecological and economic importance, playing critical roles in wood decomposition and medicinal applications. However, comprehensive genus-level mitochondrial genome analyses for Sanghuangporus remain limited, which constrains understanding of …
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Read PDFPlasma small extracellular vesicles (sEVs) are a promising liquid biopsy tool. This study aims to delineate and validate a multimodal plasma sEV biomarker signature for glioma. We use size exclusion chromatography to separate sEVs from …
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