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<h4>Background</h4>Prostate cancer (PCa) is a leading cause of cancer-related death in men worldwide. The tumor microenvironment (TME), particularly its immune and stromal components, has a critical influence on PCa progression and patient outcomes. Identifying novel …
Read PDFThe tonsil is a highly compartmentalized organ in which different microanatomical structures orchestrate designated (immune) functions. We use this already well-studied tissue to survey imaging-based spatial transcriptomics data for studying immune responses in native tissue …
Read PDFPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains …
Read PDFInsect wing development involves tissue patterning, cell fate transitions, and hormone signaling, yet its spatiotemporal logic remains unclear. The silkworm, with large wing discs and defined stages, provides an ideal model for high resolution analysis. …
Read PDF<h4>Introduction</h4>Antlers are specialized bony appendages in mammals that exhibit the remarkable ability to periodically regenerate from the pedicles and then rapidly elongate to form bone. Previous studies have demonstrated that this intricate and precise biological …
Read PDFAortic dissection is a life-threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi-target and multi-pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single-cell transcriptomics and experimental …
Read PDFThis study addressed the significant challenges in understanding the specific immune landscape and predicting patient outcomes of COVID-19, particularly in severe cases. To support clinical practice, we aimed to build a comprehensive single-cell atlas of …
Read PDFHalo nevus is an autoimmune skin disorder characterized by autoreactive CD8<sup>+</sup> T cells that target and destroy melanocytes, resulting in a depigmented perilesional halo. Yet the upstream triggers of this activation remain unclear. Here, we …
Read PDFStructural lipidomics provides comprehensive information on lipidomes, and there is great interest in applying it to single-cell analysis for accurate cell phenotyping and lipid pathway studies. However, structural lipidomics relies on tandem mass spectrometry analysis …
Read PDFTesticular sex cord stromal tumor (TSCST) is a rare testicular tumor with unknown molecular mechanisms, tumor microenvironment (TME) and limited therapeutic options. To define the molecular mechanism and potential targets of TSCST, we combined single-cell …
Read PDFRecent advancements in single-cell multi-omics technologies have significantly improved our ability to explore cellular heterogeneity at an unprecedented resolution. These innovations enable the simultaneous profiling of genomic, transcriptomic, proteomic, and epigenetic data at the single-cell …
Read PDFHypertrophied adenoids in children can impair breathing and lead to obstructive sleep apnea (OSA), often accompanied by abnormal growth and weakened stamina and immunity. However, the cause of the pathological transformation in these originally immune-enhancing …
Read PDFWe develop the spatial dissimilarity method to uncover complex bivariate relationships in single-cell and spatial transcriptomics data, addressing challenges such as alternative splicing and allele-specific gene expression. Applying this method to detect alternative splicing in …
Read PDFThe rise of single-cell sequencing has revolutionized the exploration of drug resistance, revealing the crucial role of cellular heterogeneity in advancing precision medicine. By building computational models from existing single-cell drug response data, we can …
Read PDFCoronary artery disease (CAD) is a primarily inflammatory condition caused by atherosclerosis in the coronary arteries. Increasing evidence suggests that endoplasmic reticulum (ER) stress is closely involved in the development of CAD. In the arteries …
Read PDF<h4>Background</h4>Activating anaplastic lymphoma kinase (<i>ALK</i>) mutations define a clinically relevant subset of neuroblastoma (NB), yet <i>ALK</i>-linked transcriptional programs with robust prognostic value remain insufficiently characterized. This study aimed to identify <i>ALK</i>-associated transcriptional features across single-cell …
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