Search the literature by keyword, topic, or author. Filter to articles with full text available.
10021 results
The COVID-19 pandemic significantly accelerated the development of genomic surveillance capabilities worldwide, though equitable access remains a challenge. On 12 March 2020, Guinea, a low-income country in West Africa, reported its first COVID-19 case; however, …
Read PDF<b>Background/Objectives:</b> Gamma-aminobutyric acid (GABA) is a bioactive, non-proteinaceous amino acid with potential health benefits. <i>Weissella cibaria</i> UF-274 is an important lactic acid bacterium isolated from Balinese fermented sausage (urutan) with GABA-producing abilities. The aim of …
Read PDFThe study of nontraditional model organisms, particularly those exhibiting extreme phenotypes, offers unique insights into adaptive mechanisms of stress response and survival. Snakes, with their remarkable physiological, metabolic, and morphological adaptations, serve as powerful models …
Read PDFRabies remains a major public health concern in Thailand. Nucleoprotein (N) and glycoprotein (G) genes from eight rabies-positive specimens collected during 2022 to 2024 were sequenced using Oxford Nanopore. Assemblies and phylogenetic analyses indicate genetic …
Read PDF<h4>Introduction</h4>Malaria remains a major public health challenge across sub-Saharan Africa, with Plasmodium falciparum responsible for the vast majority of cases and deaths. In Rwanda, although control measures have led to significant progress, malaria continues to …
Read PDFOur planet is inhabited by an estimated 2.5 million species of fungi, of which fewer than 10% have been scientifically described. Some of the most understudied yet remarkable fungal species are those capable of parasitizing …
Read PDFRibosomal RNAs (rRNAs) serve as species-defining markers and undergo processing steps, such as excision of intervening sequences (IVSs). Direct analysis of native rRNAs is hampered by enzyme-induced biases and by the high conservation of rRNA …
Read PDFDNA methylation offers an objective method to assess the impact of smoking. In this work, we conduct a Bayesian EWAS of smoking pack years (n = 17,865, ~850k sites, Illumina EPIC array) and extend it …
Read PDFBacterial infections remain a major global health burden, further exacerbated by the rapid emergence of antimicrobial resistance (AMR), which increases the need for accurate and timely etiological diagnosis. Conventional culture-based methods are limited by prolonged …
Read PDF<h4>Background</h4>The liverwort Apopellia endiviifolia, a dioicous, simple thalloid species, is notable for its cryptic diversity, habitat adaptability, and genomic innovation, and it represents a clade that is sister to all other Jungermanniopsida. These features make …
Read PDFThe human <i>ALKBH</i> gene family comprises nine Fe<sup>2+</sup>/α-ketoglutarate-dependent dioxygenases that catalyze the oxidative demethylation of DNA, RNA, and proteins, thereby influencing key cellular processes. Consequently, dysregulation of these enzymes has been implicated in various human …
Read PDFMolar incisor hypomineralization (MIH) is a dental condition that affects the enamel of permanent molars and/or incisors, often leading to tooth decay. Although several etiological hypotheses have come forward, including prenatal medical problems and postnatal …
Read PDF<h4>Background</h4>Carbapenem-resistant Enterobacterales pose a significant public health threat, particularly when detected in food-producing animals and retail meat. Although carbapenems are not used in European Union animal production, sporadic cases of carbapenemase-producing <i>Escherichia coli</i> have emerged …
Read PDFThe ongoing development of human artificial chromosomes (HACs) will permit investigation into essential centromere processes and the means to deliver large genetic cargoes to target cells. Starting with large (~750 kb) yeast artificial chromosome (YAC)-based …
Read PDFAfrican swine fever virus (ASFV) is highly transmissible and can cause up to 100% mortality in pigs. The virus has spread across most regions of Asia and Europe, resulting in the deaths of millions of …
Read PDFTwo yeast strains, PYCC 10015 and PYCC 10016, were isolated from soil from an Irish forest. Sequence analysis of the internal transcribed spacer (ITS) region (ITS1-5.8S-ITS2) of the rRNA gene repeat, and the D1/D2 domain …
Read PDFNo abstract available.
Read PDFWhole-genome studies in cattle play a key role in exploring both individual and population-level genetic variability. Recently, low-coverage whole-genome sequencing (0.5-2×) has been considered as an alternative to traditional approaches. Low-coverage whole-genome sequencing (lcWGS), which …
Read PDF<h4>Motivation</h4>Nanopore sequencing by Oxford Nanopore Technologies (ONT) enables direct analysis of DNA and RNA by capturing raw electrical signals. Different nanopore chemistries have varied k-mer lengths, current levels, and standard deviations, which are stored in …
Read PDF