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<b>Background:</b> The therapeutic effect and mechanism of protocatechuic aldehyde (PAL) on vascular dementia (VaD) were studied from a multi-group perspective. <b>Methods:</b> The pharmacological property of PAL was assessed by using both an in vivo two-vessel …
Read PDFBACKGROUND: Sodium overload-induced cell death is a novel mode of cell death that differs from other modes and is a very promising new target for cancer therapy. In addition, sodium overload-induced cell death plays a …
Read PDFGlioblastoma invasion into brain parenchyma presents significant challenges for treatment but remains poorly understood. In this study, we combine single-cell RNA sequencing, spatial transcriptomics, and multiplexed imaging of orthotopic xenograft models to investigate glioblastoma invasion. …
Read PDF<h4>Background</h4>Although surgery and chemotherapy remain standard treatments for colorectal cancer (CRC), immunotherapy offers a promising avenue for patients with advanced disease. However, the cellular and molecular mechanisms underlying CRC progression and immune evasion are not …
Read PDFAlzheimer's disease is characterized by complex molecular and cellular heterogeneity, which complicates efforts to identify consistent biomarkers and therapeutic targets. To better characterize the heterogeneity, we applied latent factor modeling to RNA sequencing data from …
Read PDFThe increasing availability of transcriptomic data has created new opportunities for integrating gene expression studies across biological systems and conditions. However, differences in experimental design, sequencing platforms, and sample composition introduce substantial heterogeneity, limiting direct …
Read PDFCancer cell dormancy is a clinically consequential yet computationally under-defined phenomenon characterised by reversible growth arrest and delayed disease recurrence. Although advances in single-cell and multi-omic profiling have improved detection of dormant and persister populations, …
Read PDFHepatocellular carcinoma (HCC) is characterized by substantial heterogeneity and immune tolerance, and its therapeutic efficacy is profoundly influenced by the immune microenvironment. Ferroptosis, an iron-dependent form of regulated cell death, is closely linked to tumor …
Read PDFComparative studies of vertebrate appendages offer a powerful framework for uncovering shared components of an ancestral regeneration toolkit. Here, we employed a multi-omics comparative approach leveraging the regenerative capacity of the axolotl, zebrafish, and Polypterus …
Read PDFRadiation-induced lung injury (RILI) represents a major dose-limiting complication of thoracic radiotherapy, profoundly affecting therapeutic outcomes and patient quality of life. Although RILI is clinically significant, its molecular underpinnings are not fully elucidated, hampering the …
Read PDFThe spatial organization of adaptive immune cells within lymph nodes is critical for understanding immune responses during infection and disease. Here, we introduce AIR-SPACE, an integrative approach that combines high-resolution spatial transcriptomics with paired, high-fidelity …
Read PDF<h4>Background</h4>Periodontitis is a chronic inflammatory disease driven by host immune dysregulation. However, the specific genetic regulatory mechanisms underlying this disease remain unclear. Identifying key molecular targets is crucial for precise therapeutic intervention.<h4>Methods</h4>This study integrated genome-wide …
Read PDF<h4>Background</h4>Lung adenocarcinoma (LUAD), a common lung cancer subtype, is significantly influenced by the immune microenvironment. Immune checkpoint inhibitors have shown limited efficacy in Lung adenocarcinoma due to the immunosuppressive tumor microenvironment (TME). Identifying predictive biomarkers …
Read PDFThe aim of this study was to evaluate the nephrotoxicity and molecular mechanism of Evodiamine (EVO). We combined RNA sequencing (RNA-seq) and network toxicology (NT) screening of potential target genes and signaling pathways, used molecular …
Read PDF<h4>Background</h4>Sex and atherosclerotic plaque histology are intertwined, with fibrous plaques being more prevalent in women. Plaque erosion, a significant contributor to acute coronary syndromes, is linked to fibrous plaques and is more prevalent in women …
Read PDFCellular biophysical properties are increasingly linked to disease development, including muscular dystrophy, cancer, glaucoma, and other conditions. Transcription profiles of various types have been utilized to elucidate the relationship between genes and their regulatory functions. …
Read PDFGene therapy cargo delivery to specific cell types in the central nervous system (CNS) remains a major challenge for the development of adeno-associated virus (AAV) vectors as a therapeutic modality. Here, we leverage high-plex <i>in …
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