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This study aimed to identify candidate molecular pathways mediating dopaminergic dysfunction induced by PFAS mixture exposure, with a focus on the TM/5-HT signaling axis and calcium-linked lipid metabolites, and to explore potential gut-brain axis involvement. …
Read PDFCardiovascular disease remains a leading cause of global mortality despite advances in revascularization, pharmacotherapy, and risk stratification. Immune responses to cardiovascular damage are neither temporally linear nor spatially homogeneous; they evolve across overlapping phases and …
Read PDFDilated cardiomyopathy (DCM), which develops from myocardial inflammation, is frequently linked to a poor prognosis and fatal outcome. Experimental autoimmune myocarditis (EAM) serves as an animal model of CD4<sup>+</sup> T cells-dependent acute myocarditis that is …
Read PDFSquamous cell carcinomas (SCCs) originate in epithelial tissues of older individuals who have been exposed to environmental carcinogens. Despite overlapping clinical hallmarks, SCCs from different anatomic sites have different prognoses. Here we show that fibroblasts …
Read PDFObesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD. The LC participates in feeding behavior …
Read PDFBACKGROUND: Recently, the heterogeneity of human papillomavirus (HPV) status within HPV-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) has garnered substantial attention. However, the origin and relevance of a subset of cancer cells with HPV-loss remain largely …
Read PDFBiomedical research models are undergoing continuous evolution, while conventional models (two-dimensional/ three-dimensional cultures and animal studies) face limitations in physiological relevance and ethical constraints. Against this backdrop, the integration of organ-on-a-chip (OoC) technology with multi-omics …
Read PDFWound healing is a dynamic and spatially heterogeneous process involving coordinated activity across multiple cell types. We analyze a high-resolution porcine wound-healing transcriptomic dataset of 150 samples from wound edges and centers collected across 15 …
Read PDFIn this editorial, we provide an integrative overview of MiniResource papers published in Molecules and Cells in 2024 and 2025, which establish reliable methodological practices across various fields in molecular and cellular biology. By emphasizing …
Read PDFHepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, and its progression is closely linked to the establishment of an immunosuppressive tumor microenvironment. Myristoylated alanine-rich C kinase substrate (MARCKS) has been implicated in …
Read PDF<h4>Purpose</h4>Knee osteoarthritis (KOA) is a chronic degenerative joint disease and recognized as the fourth leading cause of disability worldwide. Despite the proven clinical efficacy of electroacupuncture (EA) in alleviating KOA-related symptoms, the precise molecular mechanisms …
Read PDF<h4>Background</h4>Hypopharyngeal squamous cell carcinoma (SCC) is an aggressive malignancy with a poor prognosis, particularly in advanced stages. Concurrent chemoradiotherapy (CCRT) is frequently employed to preserve the larynx, but resistance to CCRT remains a significant clinical …
Read PDF<h4>Background</h4>Immune exclusion is a major barrier to immune checkpoint inhibitor (ICI) efficacy in gastric cancer, yet the spatial mechanisms by which m<sup>6</sup>A regulators drive this phenotype remain unclear.<h4>Methods</h4>We integrated single-cell RNA-seq, spatial transcriptomics, and functional …
Read PDFTissues are organized through the assembly of diverse cell types into multicellular structures that exhibit hierarchical spatial organization. We present HRCHY-CytoCommunity, a graph neural network framework for identifying multi-level tissue structures directly from cell-type annotated …
Read PDFINTRODUCTION: Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy of the kidney, known for its aggressive growth and tendency to metastasize. Cellular senescence (CS), regarded as a characteristic feature of the natural aging …
Read PDFMembers of <i>Geobacter sulfurreducens</i> are electroactive bacteria that transfer electrons to extracellular solid electron acceptors using extracellular electron transport (EET) pathways, thereby generating currents in bioelectrochemical systems (BESs). Studies have shown that different <i>G. sulfurreducens</i> …
Read PDF<h4>Background</h4>Tumor cell heterogeneity is a fundamental driver of breast cancer aggressiveness, underlying recurrence, metastasis, and therapy resistance. Understanding the biological characteristics and functions of specific tumor cell clusters in the tumor microenvironment is crucial for …
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