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Inferior efficacy of antibiotics (e.g. rifampicin) in M2 macrophage-dominant tuberculosis granuloma might be related to poor drug uptake into these cells, potentially mediated by altered expression and activity of drug transporters such as P-glycoprotein (P-gp, …
Read PDFGranulomas are organized inflammatory lesions formed in response to persistent stimuli such as infections. Murine infection with Leishmania donovani results in granulomas in the liver, seeded by infected Kupffer cells, and serves as a well-defined …
Read PDFBetel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single-cell RNA sequencing and spatial transcriptomics from six OSCC patients to …
Read PDFColon cancer (CC), a significant global health burden with high incidence and mortality, is often accompanied by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapy. Immunoglobulin superfamily member 9 (IGSF9), a cell …
Read PDFSpatial transcriptomics (ST) provides unprecedented insights into gene expression patterns while retaining spatial context, making it a valuable tool for understanding complex tissue architectures, such as those found in cancers. Seurat, by far the most …
Read PDFThe maternal-fetal interface represents a dynamic immunological frontier where pregnancy outcomes are determined by the delicate balance between host defense and microbial pathogenesis. Vertical transmission of pathogens across the placental barrier can lead to devastating …
Read PDFActinobacillus pleuropneumoniae (APP) is a porcine respiratory pathogen that causes significant economic losses to the global swine industry. APP-induced piglet respiratory disease complex (PRDC) is highly prevalent in winter and triggers an intense inflammatory response …
Read PDFAdamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and therapy-resistant intracranial tumor, remains a considerable clinical challenge because of its complex pathological structure, infiltrative growth, and limited treatment options. Here, integrated spatially resolved multiomics is …
Read PDFStem cell-derived organoids hold promise to model tissue-specific diseases. To enable this, it is crucial to assess how transcriptional signatures, cellular organization, and composition of organoids compare to <i>in vivo</i> counterparts. However, spatial transcriptomics has …
Read PDFSteatosis, characterized by excessive fat accumulation in the liver, is a significant precursor to chronic liver disease and hepatocarcinoma. This condition is influenced by multiple contributing factors such as obesity, alcohol consumption, and exposure to …
Read PDFColorectal cancer (CRC) liver metastases remain refractory to immunotherapy due to a profoundly immunosuppressive tumor microenvironment. Here, we conducted a prospective clinical study enrolling 18 patients with microsatellite-stable CRC liver metastases treated with high-dose radiotherapy …
Read PDFPhotosensitivity is central to cutaneous lupus erythematosus and dermatomyositis (DM), but the mechanisms linking UVB exposure to tissue-specific autoimmunity are poorly defined. Using single-cell RNA sequencing, spatial transcriptomics, proteomics, UVB provocation and in vitro modeling, …
Read PDF<h4>Background</h4>Inter-organ communication within the cardio-cerebral-renal axis orchestrates systemic homeostasis and disease progression. However, conventional methods fail to capture its spatiotemporal complexity; consequently, this creates evidence gaps in dynamic network dissection. Therefore, spatial multi-omics and organ-on-a-chip …
Read PDF<h4>Summary</h4>Spatial transcriptomics (ST) enables high-resolution exploration of tissue architecture by integrating gene expression profiles with spatial information, thereby advancing insights into cellular composition, organization, and interactions. Among ST applications, spatial domain identification is critical for …
Read PDFThe Mexican axolotl (Ambystoma mexicanum) is an established model for studying tetrapod regeneration and development. Notably, axolotls exhibit remarkable brain regeneration as adults, a trait rarely observed in other adult vertebrates. Adult axolotls can undergo …
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