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Immunotherapy has seen success in treating patients with cancer, but variable responses underscore the need for effective patient stratification and therapy planning. Computational tools integrating multi-omics, imaging and machine learning have advanced, yet reliable personalized …
Read PDFDiabetic kidney disease (DKD) lacks specific biomarkers reflecting the interplay between mitochondrial dysfunction and immune microenvironment remodeling. To address this, we integrated multi-dataset transcriptomics (GEO, MitoCarta 3.0, GeneCards) with Weighted Gene Co-expression Network Analysis, protein-protein …
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Read PDFBACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular heterogeneity and poor prognosis, necessitating novel tailored therapies. The basal and classical subtypes - driven by glycolysis versus lipid metabolism - have distinct prognostic implications warranting further …
Read PDFTemporomandibular joint (TMJ) arthritis remodels the cartilage, subchondral bone, and synovial tissue with diverse cell changes. The functional importance of the anatomical organization of TMJ cell types and cellular microenvironment in painful arthritis remains largely …
Read PDFAldosterone-producing adenomas (APAs) and micronodules (APMs) are histopathological lesions that can cause a prevalent form of secondary hypertension called primary aldosteronism. Using integrated single-cell/nucleus and spatial transcriptomics, it demonstrates substantial heterogeneity between APMs and APAs, …
Read PDFPulmonary pleomorphic carcinoma (PPC) is a rare subtype of lung cancer that comprises both epithelial and sarcomatoid components. The molecular basis of PPC, including the cellular dynamics of its components, remains largely unknown. To elucidate …
Read PDFSingle-cell RNA sequencing (scRNA-seq) has transformed the resolution of cellular heterogeneity, offering insights into dynamic biological processes from tumor evolution to immune regulation. However, its clinical translation is limited by challenges such as data sparsity, …
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Read PDFBACKGROUND: Microglia, the brain’s resident immune cells, play a pivotal role in Alzheimer’s disease (AD) pathogenesis. These cells exhibit diverse transcriptional states in response to neuroinflammatory stimuli, and characterizing these states is essential for understanding …
Read PDFSkeletal muscle has the impressive capacity to completely regenerate even after relatively severe injuries in young individuals, but this process is dysregulated in multiple cell types in the microenvironment in numerous diseases and aging. In …
Read PDF<h4>Background</h4>Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), has high incidence and poor prognosis. Although anti-programmed cell death protein 1 (PD1) therapy and epidermal growth factor receptor (EGFR) inhibitors benefit some patients, …
Read PDFSepsis is a major cause of global neonatal mortality, affecting 1.3 to 1.9 million neonates worldwide. Accurate diagnoses and effective treatment of sepsis during the onset is essential to improve outcomes. Current efforts to develop …
Read PDFGastric cancer (GC) presents a significant global health challenge with a poor prognosis due to late detection. This study combines single-cell RNA sequencing and bulk transcriptomics to identify senescence-related gastric cancer genes (SGCGs) as diagnostic …
Read PDFThe peripheral myelin protein P2 (also known as PMP2/FABP8) has two basic functions in vivo: the transport of fatty acids within the cell to the target compartments and the adhesion of lipid bilayers in the …
Read PDF<h4>Background</h4>Tuberculosis (TB) treatment response prediction is critical for personalized care. We developed an ensemble Transformer framework integrating clinical and transcriptomic data from 467 patients and five GEO datasets (GSE83456, GSE107995, GSE158802, GSE19435, GSE25534).<h4>Methods</h4>Five diverse Transformer …
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