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Omics-based insights into skin ulcerative disease in sea cucumbers: a systematic review
Skin ulcerative disease (SUD) in sea cucumbers poses a significant threat to marine biodiversity, aquaculture sustainability, and ecosystem health. Characterized by localized lesions that can progress to extensive tissue necrosis, SUD arises from complex interactions …
Read PDFCo-regulation of microglial subgroups in Alzheimer's amyloid pathology: Implications for diagnosis and drug development
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. Neuroinflammation drives AD progression and therefore represents a promising target for diagnosis and therapy. In early AD, microglia polarize into pro-inflammatory …
Read PDFLow NDFIP1-driven metabolic alterations in CD8 + T cells: implications for immune evasion and therapy resistance in HNSC
Head and neck squamous cell carcinoma (HNSC) is an aggressive malignancy often resistant to therapy, especially in advanced stages. Metabolic reprogramming, marked by shifts in glycolysis and oxidative phosphorylation (OXPHOS), is crucial for tumor progression …
Read PDFThe I148M PNPLA3 Variant Forces Progressive Portal MASLD by Spatially Perturbing Metabolic Pathways Across Liver Zones
Genetics strongly impacts the course of metabolic dysfunction-associated steatotic liver disease (MASLD), with the I148M <i>Patatin like phospholipase domain containing 3</i> (<i>PNPLA3</i>) variant representing the main modifier. Fat accumulation in the hepatic lobule, strongly enhanced …
Read PDFMaternal opioid use and hepatitis C infection disrupt the placental immune landscape and structure
Maternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed …
Read PDFInherent variability limits clinical utility of reproducible Parkinson's transcriptomics signatures
Blood transcriptomic signatures for Parkinson's disease (PD) diagnosis have failed to integrate into clinical practice despite decades of translational efforts. We evaluated the classification performance of 13 published coding RNA-based signatures using both a large …
Read PDFInfluence of APOEε4 on Blood Transcriptomics in Cognitively Impaired Individuals
No abstract available.
Read PDFFactors Impacting Meat Product Quality: From Farm to Table
Meat quality is a complex and dynamic trait, resulting from the integration of biological, nutritional, environmental, and technological factors operating across the entire production chain, from primary production systems to consumer handling [...].
Read PDFSpatiotemporal transcriptomic and metabolomic landscapes of wild soybean seed development reveal regulatory mechanisms of nutrient accumulation
Seed development is a pivotal stage of the soybean life cycle, directly determining yield and nutritional quality related to oil and protein contents. However, the spatiotemporal mechanisms underlying cell differentiation and nutrient accumulation during seed …
Read PDFInfluence of APOEε4 on Blood Transcriptomics in Cognitively Impaired Individuals
No abstract available.
Read PDFApoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery
<h4>Background</h4>Early detection of drug-induced liver injury (DILI) during drug development is crucial for reducing drug attrition and ensuring the safety of patients. A versatile, biologically interpretable, and dose-dependent screening approach is therefore needed to inform …
Read PDFMulti‑omics and their integration in psoriasis research (Review)
Psoriasis is a chronic, immune‑mediated skin disorder characterized by keratinocyte hyperproliferation, inflammatory infiltrates and systemic comorbidities. While genetic predisposition and immune dysregulation are established contributors, recent advancements in high‑throughput omics technologies have provided deeper insights …
Read PDFA technical comparison of spatial transcriptomics platforms across six cancer types
<h4>Background</h4>Spatial transcriptomics (ST) technologies are reshaping our understanding of tissue organization and cellular context in health and disease. However, technical benchmarking across platforms remains limited, particularly in formalin-fixed, paraffin-embedded (FFPE) clinical samples, which represent the …
Read PDFSignal-based spatial domain identification of spatially resolved transcriptomics with multigraph fusion
Spatially resolved transcriptomics (SRT) measures transcriptomes of cells within intact biological tissues, providing unprecedented opportunities to investigate tissue micro-environments, where spatial domains are modeled as clusters of spatially neighboring cells. Current methods for the identification …
Read PDFiS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk
Large language models (LLMs) have demonstrated impressive capabilities in summarization, reasoning, and content generation, yet their inability to directly interpret large-scale omics data has limited their utility in data-driven hypothesis generation-particularly in mechanism discovery that …
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