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Glioblastoma is an aggressive brain cancer with limited treatment options and poor patient survival, driven in part by cellular diversity within tumors. While individual cell types have been catalogued, how malignant, vascular, and immune cells …
Read PDFLocal protein synthesis is vital for neuronal function, but its dysregulation in neurodegenerative diseases remains poorly defined. Here we applied spatial transcriptomics to adult mouse motor nerve axons and cell bodies to enable subcellular mapping. …
Read PDF<h4>Study question</h4>Does the analysis of endometrial microbes provide the same information when using DNA or RNA sequencing-based techniques?<h4>Summary answer</h4>DNA vs RNA-based microbial analysis techniques demonstrated significant microbial compositional differences and lack of transcriptionally active lactobacilli …
Read PDFFertility is a multifactorial trait and a key determinant of productivity and sustainability in beef cattle production. Identifying molecular mechanisms and biomarkers associated with fertility could improve the prediction of reproductive potential in beef heifers. …
Read PDFBACKGROUND: Neutrophil extracellular traps (NETs) facilitate hepatocellular carcinoma (HCC) progression, but the upstream cellular organizers and the histopathological correlates of NETosis-prone niches remain poorly defined. We aimed to build a pathology-to-single-cell framework to (i) quantify …
Read PDF<h4>Introduction</h4>Cancer-associated fibroblasts (CAFs) are integral components of the tumor microenvironment that modulate the response to immune checkpoint inhibitors, particularly in breast cancer. However, the specific roles of CAF subtypes in regulating the efficacy of anti-PD-1 …
Read PDF<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC), an aggressive cancer with poor prognosis, poses major challenges owing to late diagnosis and limited response to current therapies. However, the identification of candidate drugs through multi-omics analyses and therapeutic peptides …
Read PDF<h4>Background</h4>Tertiary lymphoid structures (TLSs) promote antitumor immunity and predict favorable immunotherapy outcomes in breast cancer. The study aimed to investigate how Tryptophan 2,3-dioxygenase (TDO2)-associated tryptophan metabolism influences TLS maturation and B cell class switching in …
Read PDF<h4>Background</h4>The orbitofrontal cortex (OFC) represents a promising yet underexplored neuromodulation target for negative symptoms in schizophrenia, and the macroscale and microscale mechanisms underlying its therapeutic effects remain unclear.<h4>Methods</h4>In a randomized, double-blind, sham-controlled trial, 84 patients …
Read PDF<h4>Background</h4>Severe COVID-19 is associated with dysregulated immune responses. Immune responses heterogeneity was previously reported during the first waves of the pandemic. We aimed to characterise mucosal transcriptomic profiles in critically-ill patients during the Omicron era.<h4>Methods</h4>This …
Read PDF<i>Thamnaconus septentrionalis</i> is an emerging commercially important aquaculture species in China, distributed extensively in the Indo-West Pacific Ocean. Recently, because of the seriously declining population and considerable economic potential of this aquaculture fish, increasing attention …
Read PDF<h4>Background</h4>Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However, the spatial and single-cell …
Read PDFHyperlipidemia is a major risk factor for cardiovascular disease, yet effective dietary interventions remain underexplored. Pomegranate (POG) has been recognized for its potential lipid-lowering effects, but its underlying mechanisms require further investigation. To elucidate the …
Read PDFChildhood is a critical period for hematopoietic development and susceptibility to hematologic disease. Here we generated a multimodal single-cell atlas of healthy human bone marrow, capturing mRNA and surface protein expression in 90,710 cells, including …
Read PDF<h4>Background</h4>Cancer-associated fibroblasts (CAFs) are increasingly recognized as critical contributors to the limited efficacy of immunotherapy, particularly through the establishment of immune-excluded tumor microenvironments. However, the functional heterogeneity and spatial ecological roles of CAFs in melanoma …
Read PDFIntercalary meristems (IcMs), specialized developmental zones that drive rapid stem elongation in monocots, exhibit distinct spatiotemporal dynamics; however, their genetic basis remains poorly understood due to their transient activity and cellular heterogeneity. Moso bamboo (<i>Phyllostachys …
Read PDFLnCeVar 2.0 (available at http://bio-bigdata.hrbmu.edu.cn/LnCeVar or http://www.bio-bigdata.net/LnCeVar) is an updated database investigating genomic variations that disrupt competing endogenous RNA (ceRNA) networks via single-cell and spatial transcriptomics. Enhancements include expanded data and improved features: (i) 16 …
Read PDFAdvances in cardiac regenerative medicine increasingly rely on integrating artificial intelligence with spatial multi-omics technologies to decipher intricate cellular dynamics in cardiomyocyte differentiation. This systematic review, synthetising insights from 88 PRISMA selected studies spanning 2015-2025, …
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