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Skeletal muscle homeostasis and repair depend on the activation of tissue resident stem cells called satellite cells. To understand the early molecular basis of human satellite cell activation, epigenomics, transcriptomics and protein analysis were performed …
Read PDFGenome-wide association studies have identified thousands of disease-associated loci, yet their biological interpretation remains limited. We propose joint pleiotropic and epigenomic partitioning (J-PEP), a clustering framework that integrates pleiotropic SNP effects on auxiliary traits and …
Read PDFNon-communicable diseases (NCDs) impose an overwhelming burden on global health systems. Prevailing healthcare for NCDs remains largely hospital-centered, episodic, and reactive, rendering them poorly suited to address the long-term, heterogeneous, and multifactorial nature of NCDs. …
Read PDFPrecision healthcare is increasingly oriented toward the development of therapeutic strategies that are as individualized as the patients receiving them. Central to this paradigm shift is artificial intelligence (AI)-enabled multi-modal data integration, which consolidates heterogeneous …
Read PDFMetastatic brain tumors undergo profound metabolic-epigenetic reprogramming driven by the unique constraints of the brain microenvironment. Hypoxia-inducible factor-1α (HIF1α) enhances glycolytic flux, lactate accumulation, and histone lactylation, collectively supporting metastatic colonization and immune evasion. Key …
Read PDF<h4>Background</h4>Low-dose computed tomography (LDCT) lung cancer screening can reduce mortality in high-risk individuals, but many individuals with a heavy smoking history may be reluctant to undergo radiologic examinations. A non-invasive blood test might help overcome …
Read PDFDiabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and …
Read PDF<b>Background</b>: Malnutrition in amyotrophic lateral sclerosis (ALS) is associated with disease severity, and epigenetic regulation may be involved. The aim of this study was to assess the methylation levels of specific DNA sequences from the …
Read PDF<h4>Background</h4>Endocrine therapy with tamoxifen (TAM) or aromatase inhibitors (AI) is an effective treatment of patients with estrogen receptor-positive, HER2-negative luminal breast cancer. However, many patients do not respond to this therapy, leading to disease recurrence. …
Read PDFHorticultural crops, including fruits, vegetables, ornamental plants, and tea plants, are vital for economic and nutritional sustainability, yet their cultivation is severely hampered by abiotic stresses such as heat, cold, and salinity. The advent of …
Read PDF<b>Background</b>: Gene expression and cellular identity are regulated by epigenetics that occurs through chromatin modifications, RNA changes, chromatin accessibility, and three-dimensional genome organization. Although DNA methylation has been the focus of most epigenetics studies in …
Read PDFCervical cancer remains the fourth most common cancer among women globally, disproportionately impacting low- and middle-income countries despite the existence of HPV vaccines. While DNA methylation has been studied extensively as a biomarker, other epigenetic …
Read PDFTrees are integral to ecosystems and hold considerable economic importance. Their exceptional longevity and modular structure also make them valuable models for studying the long-term accumulation of somatic mutations and epimutations in plants. Empirical evidence …
Read PDFInduced pluripotent stem cells (iPSCs) enabled the generation of diverse cell types; however, certain fundamental biological properties, such as the genetic and epigenetic determinants of proliferation, remain poorly characterized. We quantified proliferation across 602 unique …
Read PDFCardiovascular diseases constitute a marked threat to global health, and the emergence of spatial omics technologies has revolutionized cardiovascular research. This review explores the application of spatial omics, including spatial transcriptomics, spatial proteomics, spatial metabolomics, …
Read PDFThe rapid advancement of spatial multi-omics technologies has opened new avenues for dissecting tissue architecture with unprecedented resolution. However, inherent disparities across omics modalities, such as differences in biological hierarchy and resolution, pose significant challenges …
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