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Full text 2025

Statistical Methods for Multi-Omics Analysis in Neurodevelopmental Disorders: From High Dimensionality to Mechanistic Insight

Airoldi M, Remori V, Fasano M.

Neurodevelopmental disorders (NDDs), including autism spectrum disorder, intellectual disability, and attention-deficit/hyperactivity disorder, are genetically and phenotypically heterogeneous conditions affecting millions worldwide. High-throughput omics technologies-transcriptomics, proteomics, metabolomics, and epigenomics-offer a unique opportunity to link genetic variation …

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Epigenetics Single-Cell Transcriptomics
Full text 2025

Epigenetic Regulation of Floral Transition

Li Y, Zhang D, Wang J, et al.

As an emerging field of life science, epigenetics plays a pivotal role in regulating gene expression. Epigenetic modifications including histone modifications, DNA methylation, chromatin remodeling, non-coding RNAs, and RNA modifications (particularly m<sup>6</sup>A methylation) play crucial …

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Epigenetics
Full text 2025

Computational whole-body-exposome models for global precision brain health

Ibáñez A, Duran-Aniotz C, Migeot J, et al.

The worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely …

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Bioinformatics
Full text 2025

The functional and therapeutic potential of epitranscriptomics in breast cancer

Thompson RL, Lothion-Roy J, Bellows E, et al.

Breast cancer (BCa) is one of the most commonly diagnosed malignancies worldwide and is clinically heterogenous. BCa is classified into distinct histopathological and molecular subtypes that inform diagnosis, treatment, and prognosis. Although therapeutic advances, particularly …

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Epigenetics
Full text 2025

Phenotype-Driven Variability in Longitudinal Body Composition Changes After a Very Low-Calorie Ketogenic Intervention: A Machine Learning Cluster Approach

de la O V, de Cuevillas B, Henkrich M, et al.

<b>Background</b>: Obesity is a major global public health issue with no fully satisfactory solutions. Most nutritional interventions rely on caloric restriction, with varying degrees of success. Very low-calorie ketogenic diets (VLCKD) have demonstrated rapid and …

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Bioinformatics
Full text 2026

Maternal antioxidant supplementation enhances oxidative balance, milk bioactivity, and neonatal performance in Beetal goats during the transition period

Zaib G, Zhiwei K, Yaseen A, et al.

<h4>Background and aim</h4>Pregnancy and early lactation in small ruminants are characterized by heightened metabolic activity and increased production of reactive oxygen species, predisposing animals to oxidative stress and reduced productivity. Despite extensive research in dairy …

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Bioinformatics
Full text 2026

Radiogenomics: Current Understandings and Future Perspectives

Zhang X, Lai Q, Cao J, et al.

Radiogenomics is a rapidly developing field that links radiological image features (radiomics) to genomic-level data (genomics, transcriptomics, and epigenomics), addressing the limitations of single-omic approaches. Radiomics provides a noninvasive and cost-effective method to capture tissue-level …

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Epigenetics Transcriptomics
Full text 2025

The Art of Nanoimmunobiotechnomedicine in Depression Management

Anurogo D, Ratnasari RT, Irmania N, et al.

<h4>Purpose</h4>To explore the role of nanoimmunobiotechnomedicine in depression management, emphasizing how nanotechnology and immunobiology offer innovative approaches to understanding and treating depression. We investigated the molecular mechanisms underlying depression and integrated multi-omics approaches such as …

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Bioinformatics Epigenetics