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Here, we present an optimized high-resolution Hi-C protocol for human breast tissues using the Phase Genomics Proximo Hi-C Kit. We describe steps for liquid nitrogen tissue processing, crosslinking, and quenching, followed by cell lysis and …
Read PDFMule deer (Odocoileus hemionus) is an ecologically and economically important cervid species which is widely distributed across western North America. Their broad range and use of diverse habitats, including those linked to historical glacial refugia, …
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Read PDFN<sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most prevalent epitranscriptomic modification in plant mRNAs, functions as a critical regulatory layer governing environmental response. Refrigeration reduces transcripts of cell wall enzymes to delay softening, however whether m<sup>6</sup>A participated in this …
Read PDFPhyllospadix spp. (surfgrass) are flowering plants and keystone species in the rocky intertidal and subtidal environments of the North Pacific Ocean. Here we report a chromosome level assembly for P. torreyi, which occurs along the …
Read PDFGWAS-associated variants of related complex traits indicate the presence of pleiotropic clusters often related to tissue-specific epigenomic profiles. The authors introduce J-PEP, a novel framework that enables tissue-aware interpretation of complex trait genetic architecture and …
Read PDFHere, we present a significant update to the MeDReaders database and webserver. The new MeDReaders 2.0 covers interactions between transcription factors (TFs) and DNA cytosine modifications that arise during DNA methylation and active demethylation, including …
Read PDFOvarian cancer (OC) is a predominant cause of fatality amongst gynecological malignancies, frequently identified at its later stages owing to its asymptomatic characteristics and the absence of adequate screening techniques. Imaging techniques such as ultrasound …
Read PDFUnderstanding chromatin dynamics across the cell cycle is crucial, as the structural transitions of chromosomes are fundamental to processes including transcriptional regulation, DNA replication, and faithful chromosome segregation. Although chromatin undergoes extensive reorganization throughout the …
Read PDFThe northern elephant seal (Mirounga angustirostris) is the largest pinniped species in the northern hemisphere. The species is classified as being of least conservation concern by the IUCN-a triumph of conservation efforts despite hunting pressure …
Read PDFCarcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional immunomodulatory protein involved in both immune activation and immune suppression across diverse cancer types. However, its biological significance and clinical relevance in sarcoma (SARC) remain …
Read PDFDrought stress is the most pervasive abiotic constraint on global crop productivity, with projected intensification under climate change threatening the yields of staple crops including wheat, rice, maize, and legumes. Conventional breeding approaches have delivered …
Read PDFMitral valve disease (MVD), particularly mitral valve prolapse (MVP), is a common heart valve condition affecting millions of people worldwide. Its pathological mechanism is complex, involving multiple factors such as extracellular matrix remodeling, inflammatory responses, …
Read PDFFremontodendron (Malvaceae) is a genus of shrubs native to the California Floristic Province (CFP) with dense, stellate trichomes on their leaves (hence the common name "flannelbush"). The current treatment of the genus includes the widespread …
Read PDFThis review aims to provide a comprehensive overview of recent advances in the genomics of multiple myeloma and their clinical implications. Multiple myeloma is a hematologic malignancy originating from bone marrow plasma cells, characterized by …
Read PDFPathological cardiac remodeling involves cell-type-specific regulatory changes that require integrative analysis across all cardiac cell populations. Here, we present a protocol for isolating single nuclei from fresh-frozen murine cardiac ventricular tissue to enable the integrated …
Read PDFDue to late diagnosis, high molecular diversity, and limited response to therapeutic intervention, gastrointestinal (GI) cancers result in a considerable number of cancer-related deaths. Classic clinicopathological classification and single omics analysis fail to adequately convey …
Read PDF<h4>Introduction</h4>Uterine fibroids are the most common benign gynecological tumors, affecting up to 70-80% of women, yet still lack clinically validated biomarkers for disease stratification, monitoring, or therapeutic targeting. Advances in multi-omics technologies offer unprecedented opportunities …
Read PDFThe ornate shrew (Sorex ornatus) is a small predatory mammal with a broad distribution in northern, central, and southern California as well as in Baja California, Mexico. The ornate shrew is a highly productive consumer …
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