Search the literature by keyword, topic, or author. Filter to articles with full text available.
784 results
<h4>Background</h4>Lung cancer (LC) remains the leading cause of cancer-related mortality worldwide. Its poor prognosis is largely attributed to late-stage diagnosis, highlighting the need for sensitive, minimally invasive biomarkers for early detection. In this study, we …
Read PDFThe explosive expansion of fish multi-omics data is reshaping basic and applied research in fisheries and aquaculture. Here, we introduce iFish, a rigorously curated and comprehensive resource that integrates genome, transcriptome, epigenome, and proteome datasets …
Read PDFRheumatoid arthritis (RA) is a multifaceted autoimmune disease that is marked by a complex molecular profile influenced by an array of factors, including genetic, epigenetic, and environmental elements. Despite significant advancements in research, the precise …
Read PDFThe blood - brain barrier (BBB) is a dynamic regulator of brain homeostasis, and its dysfunction is a hallmark of many neurological and psychiatric disorders. Yet, in most conditions, the causal relationship between BBB injury …
Read PDF<h4>Background</h4>Epigenetic dysregulation plays a pivotal role in cancer immune evasion by orchestrating tumour antigen silencing, immune cell dysfunction, and the formation of an immunosuppressive microenvironment. By disrupting successive phases of the cancer-immunity cycle-from antigen presentation …
Read PDFMetabolic disorders, including obesity, type 2 diabetes, metabolic syndrome, and fatty liver disease, reflect multifactorial interactions among diet, host genetics, the environment, and the gut microbiome. However, conventional population-level dietary guidance often fails to capture …
Read PDFOral squamous cell carcinoma (OSCC) remains a formidable challenge in modern medicine, threatening enormous number of lives worldwide. Although research is offering an exponential growth as numbers of molecular pathways, biomarkers, and potential therapeutic targets …
Read PDFThe metastatic tumor microenvironment (TME) is a highly dynamic and heterogeneous ecosystem that plays a critical role in promoting cancer cell colonization, immune escape, and resistance to therapy. Recent advances in multi-omics technologies-including genomics, transcriptomics, …
Read PDF<h4>Background</h4>Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting the urgent need for earlier detection within real-world screening and patient management pathways. Recent advances in multi-omics technologies have created new opportunities for identifying …
Read PDFAbiotic stresses such as drought, salinity, heat, and cold are the most critical factors limiting global crop productivity, posing significant challenges to food security and the sustainability of agricultural systems. Epigenetic modifications, including DNA methylation, …
Read PDF<h4>Background</h4>Chronic inflammation and DNA methylation are potential mechanisms in dementia etiology. The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk remains understudied. We explored the association of inflammatory cytokines with cognitive …
Read PDFEndometriosis affects an estimated 5-10% of women of reproductive age and presents with substantial clinical and biological heterogeneity. Recent clinical guidelines have shifted toward symptom-guided diagnosis supported by expert imaging, moving away from mandatory diagnostic …
Read PDFIntra-tumoral heterogeneity (ITH) is common in malignant tumors and arises from dynamic variations across genetic, epigenetic, transcriptomic, proteomic, metabolic, and microenvironmental factors. This complexity drives tumor evolution and treatment resistance, undermining the accuracy of clinical …
Read PDF<h4>Background</h4>Exposure to smoke from biomass combustion is a significant environmental risk factor for chronic obstructive pulmonary disease (COPD). Through epigenome-wide association studies (EWAS), changes in DNA methylation levels associated with pathological conditions can be identified. …
Read PDF<h4>Aim</h4>We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups.<h4>Methods</h4>We used whole-blood methylome profiles for 5,146 ALS patients and 2,156 …
Read PDFHenoch-Schönlein purpura (HSP) is a common autoimmune disease in children. The lesions primarily involve small vessels in the skin, kidneys, joints and intestines. Henoch-Schönlein purpura nephritis (HSPN) caused by HSP is the main factor affecting …
Read PDFCan individual cells retain a memory of past gene expression levels even after the stimulus has faded? In this issue of Cell Genomics, Domitilla Del Vecchio and colleagues describe an analog epigenetic memory system in …
Read PDF