Search the literature by keyword, topic, or author. Filter to articles with full text available.
2701 results
Decidualization of human endometrial stromal cells (HESCs) is one of the critical steps in the establishment of human pregnancy. Nevertheless, little is known about the molecular mechanisms underlying human decidualization. In this study, we identified …
Read PDFTranscription factor (TF) upregulation accompanies many cellular state transitions, yet how increased TF abundance impacts gene regulation remains unclear. Two broad models are often invoked, whereby higher TF levels amplify the expression of preexisting target …
Read PDFDark-induced senescence (DIS) is a coordinated physiological process associated with chlorophyll degradation, macromolecular turnover, and nutrient remobilization under prolonged darkness. <i>EXO70B1</i>, a subunit of the exocyst complex, has been implicated in intracellular membrane trafficking, autophagy-associated …
Read PDF<h4>Background</h4>Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by malignant transformation of lymphoid precursor cells. ALL prognosis differs considerably, especially between pediatric patients and adult patients, with poor response to therapy in adults. MicroRNAs …
Read PDFZFP36L2 (zinc finger protein 36 like 2, C3H type-ZFP) is an RNA-binding protein targeting transcripts rich in adenine-uridine elements (AREs). Previous transcriptomic analysis suggested that ZFP36L2 displays a distinct transcript preference or 'specific activity'. However, …
Read PDF<i>Streptococcus pyogenes</i> or Group A Streptococcus (GAS), a significant human pathogen, employs quorum sensing (QS) systems to coordinate its behavior and genetic regulation to enhance survival. Our previous research established that one such QS system, …
Read PDFCD4+ T helper (TH)-17 cells play a pivotal role in mucosal immune defense and are implicated in autoimmune diseases and cancer. Although Th17 cell plasticity is well-studied in mice, the factors driving their transition between …
Read PDFWeed control of solanaceous weeds growing with solanaceous crops is a constant challenge. Infected by viruses, they can also act as virus reservoirs, complicating this problem further. Viromes of annual <i>Solanum nigrum</i>, <i>Datura stramonium</i>, and …
Read PDFTo investigate the compensatory role of α-cell-derived paracrine signaling through glucagon and GLP-1 receptors in maintaining β-cell function when insulin secretion is compromised. A β-cell-specific Nox4 knockout mouse (Nox4<sup>βKO</sup>) displays defective glucose-stimulated insulin secretion and …
Read PDFAllele-specific expression (ASE) analyses from RNA-Seq data provide quantitative insights into genomic imprinting and the genetic variants that affect transcription. Robust ASE analysis requires the integration of multiple computational steps, including read alignment, read counting, …
Read PDFThe malaria parasite mitochondrial proteins are critical targets for antimalarial drugs, however, the emergence of drug resistance against the existing protein targets necessitates novel therapeutic approaches. In this study, we profiled mitochondrial sense and natural …
Read PDFBACKGROUND: Cisplatin plus 5-fluorouracil (CF) remains a cornerstone of treatment for locally-advanced esophageal cancer (EC). However, resistance to CF-based neoadjuvant chemotherapy (NAC) remains a major clinical challenge. Clarifying whether resistance-associated molecular features are induced by …
Read PDF<h4>Introduction</h4>Scrub typhus is an emerging and neglected tropical disease caused by <i>Orientia tsutsugamushi</i> (<i>Ot</i>). Immunity in scrub typhus patients is known to be short-lived; however, its underlying mechanisms remain unclear. No reports have examined humoral …
Read PDFCancer stem cells (CSCs) constitute a subpopulation of malignant cells with self-renewal and differentiation capabilities that drive tumorigenicity, metabolic adaptability, immune evasion, and therapeutic resistance, key factors contributing to metastasis and poor clinical outcomes. While …
Read PDFSleep plays a critical role in animal physiology, primarily governed by the brain, and its disruption is prevalent in various brain disorders. Mettl5 is associated with intellectual disability (ID), which often includes sleep disturbances. However, …
Read PDFThe hypothalamus is a conserved structure in the brain of vertebrates that plays key roles in the organism's homeostasis through different functions, including regulation of temperature, sleep, energy balance and reproduction. The hypothalamus is composed …
Read PDFThe cricket Gryllus bimaculatus presents a compelling model for investigating neuroplasticity due to its unusual capability of adult structural reorganization. The molecular pathways underlying these changes remain poorly understood. Here, we reanalyzed RNAseq data, originally …
Read PDFRNA sequencing libraries are typically processed before sequencing. We compared the performance of automated mRNA enrichment (autoE) and manual mRNA enrichment (manE) with globin depletion, and automated rRNA depletion (autoD) with globin depletion prior to …
Read PDFAggravation of pyrethroid resistance threatens malaria control; yet, its molecular basis remains elusive. This study used a comprehensive multi-omics framework integrating 7-year gap temporal RNA-Seq, PoolSeq Whole Genome, and functional analyses, to uncover resistance escalation …
Read PDFChronic hepatitis B virus (HBV) is a leading cause of liver disease and hepatocellular carcinoma that persists as a DNA mini-chromosome and replicates via genomic RNA intermediates. While HBV replication has been extensively studied, mechanisms …
Read PDF