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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, and transcatheter arterial chemoembolization (TACE) remains the core locoregional therapeutic modality for patients with intermediate to advanced disease. However, a considerable proportion …
Read PDFThe Triticeae tribe, encompassing staple crops like bread wheat (Triticum aestivum), barley (Hordeum vulgare), and rye (Secale cereale), underpins global food security due to its agronomic importance and genetic diversity. While RNA-seq has revolutionized transcriptome …
Read PDFSmoking is a major modifiable risk factor for myocardial infarction (MI); however, the molecular mechanisms through which its core component nicotine and its primary metabolite cotinine mediate MI development remain incompletely understood. This study aimed …
Read PDFBone and skeletal muscle are essential components of musculoskeletal system, enabling movement, load-bearing, and systemic homeostasis. These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines, growth factors, and extracellular-matrix (ECM) proteins. The spatial organization …
Read PDFSingle-cell RNA sequencing (scRNA-Seq) enables analysis of gene expression at single-cell resolution. RNA velocity analysis infers the temporal dynamics of transcriptional states from the relative abundances of spliced/unspliced mRNA quantified via scRNA-Seq. Classical RNA velocity …
Read PDFThe polychaete Capitella teleta is a primary model for evolutionary developmental biology, comparative genomics, conservation, and ecotoxicology. Although it was the first polychaete genome sequenced, the original assembly is outdated by modern standards. Here, we …
Read PDFFinger millet (<i>Eleusine coracana</i> (L.) Gaertn.) is a resilient yet underutilized cereal with exceptional potential to withstand adverse environmental conditions. Despite its adaptability, the genetic and physiological bases of its stress tolerance remain insufficiently characterized …
Read PDFShoot flushing is a critical determinant of grafted seedling quality in Camellia oleifera, with key evaluation metrics including flushing timing, new shoot number and growth rate, and seedling height uniformity. To elucidate the molecular mechanisms …
Read PDFBACKGROUND: Tumor heterogeneity poses a major challenge to elucidating the mechanisms underlying tumor progression and metastasis. However, the cellular heterogeneity of triple-negative breast cancer (TNBC) remains incompletely understood. METHODS: We performed an integrated analysis of …
Read PDFPalmitoylation, a critical post-translational modification mechanism, plays a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progression. While multiple palmitoylated proteins have been reported to regulate HCC development, systematic characterization of palmitoylation-associated gene signatures and …
Read PDFIntegrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative …
Read PDFPichia kudriavzevii tolerance mechanisms are not well understood, even though strong-flavor Baijiu fermentation places a heavy burden on yeast metabolism due to the accumulation of lactic acid (LA). This study utilized growth kinetics, electron mi-croscopy, …
Read PDF<h4>Background/aim</h4>Chemotherapy with gemcitabine and cisplatin remains the cornerstone of treatment for advanced urothelial carcinoma (UC), yet response rates vary significantly among patients. Predicting treatment response is crucial to avoid unnecessary toxicity and optimize therapeutic strategies. …
Read PDF<h4>Background</h4>In chronic kidney disease (CKD), there is evidence of loss of function and fibrosis in the progression of tubular epithelial cells; however, the cellular heterogeneity and underlying molecular mechanisms are not well defined. Knowledge of …
Read PDFBeetleAtlas is an online resource for tissue- and stage-specific transcriptomics in the red flour beetle, Tribolium castaneum. On updating from the original Tcas5.2 genome assembly to the more recent improved icTriCast1.1 genome assembly it became …
Read PDFBACKGROUND: Spermatozoa are produced in the testis and acquire motility and fertilizing capacity during post-testicular maturation in the epididymis, a highly region-specific process. How gene loss reshapes region-specific transcriptional programs along the testis–epididymis axis remains …
Read PDFTo explore the allelopathic response mechanism of Elymus nutans to the extracts of Ligularia sagitta, seed germination tests combined with integrated transcriptome and metabolome analyses were performed to systematically investigate the effects of the extracts …
Read PDFEpigenetic features, such as histone modifications and higher-order genome organization, are fundamental determinants of cell-specific gene expression. However, while the HL-1 cell line is a widely utilized model for cardiac research, a comprehensive and integrated …
Read PDF<h4>Background/aim</h4>Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with poor prognosis due to drug resistance and recurrence. Tumor-associated macrophages (TAMs) are pivotal in the HCC tumor microenvironment, but their prognostic and therapeutic relevance remains incompletely …
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