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The life cycle of <i>Plasmodium falciparum</i> is characterized by complex regulatory changes that allow adaptation of the parasites to different environmental conditions, which are especially pronounced during transmission between the mammalian host and the insect …
Read PDFThe Yarkand hare (Lepus yarkandensis) is endemic to the Tarim Basin in Xinjiang, China. It is a key species and a critical component of the Tarim Basin ecosystems. However, the lack of a reference genome …
Read PDFSalicornia depressa (American pickleweed) is the most widespread member of its salt-loving genus in North America. Pickleweeds typically colonize high marsh areas that tides make highly saline. Most other salt marsh plants cannot withstand the …
Read PDFBladder cancer is a challenging disease with high recurrence rates and limited treatment options. Studies have highlighted the role of ferroptosis, an iron‑dependent cell death mechanism, in cancer progression and treatment. In the present study, …
Read PDFUnderstanding the molecular mechanisms underlying disease resistance in Salmo trutta fario is of fundamental importance for enhancing the health and sustainability of salmonid aquaculture. In this study, we performed an integrative multi-omics analysis combining transcriptome …
Read PDF<h4>Background</h4>The genus <i>Artocarpus</i> includes about 70 species, such as the economically important jackfruit and breadfruit, which serve as vital sources of food, timber, and medicine in the tropics. However, systematic research and genetic improvement have …
Read PDFPooled CRISPR screening combined with single-cell RNA sequencing (scRNA-seq) has emerged as a powerful strategy for dissecting gene function and reconstructing gene regulatory networks (GRNs) in complex biological systems. This approach enables high-throughput, parallel perturbation …
Read PDFLeukocytes at the maternal-fetal interface have critical functions during pregnancy in the prevention of maternal reactivity towards fetal alloantigens, suppression of excess inflammation and promotion of placental angiogenesis. Failed maternal immune adaptations to pregnancy can …
Read PDF<h4>Objectives</h4>Ischemic stroke represents a major global cause of disability and death. Timely recanalization of occluded vessels to salvage the ischemic penumbra is the cornerstone of acute ischemic stroke (AIS) treatment. Nevertheless, the molecular mechanisms driving …
Read PDFOver the past three decades, advances in high-throughput technologies have played a major role in the transformation of biomedical science, which has enabled unprecedented exploration of genomes, transcriptomes, and proteomes [...].
Read PDF<h4>Background</h4>Postmenopausal osteoporosis (PMO) develops as a result of pathological cross-tissue interactions. However, current experimental paradigms are constrained by their single-tissue focus, hindering efforts to discover systemwide regulatory genes.<h4>Objective</h4>We aimed to discover conserved genetic regulators of …
Read PDFIpomoea pes-caprae (IPC) is a perennial halophytic vine with remarkable salt and drought tolerance, playing a critical ecological and medicinal role in tropical and subtropical coastal ecosystems. Despite the availability of a high-quality chromosome-level reference …
Read PDFBACKGROUND: The formation of enamel occurs across multiple developmental stages and is highly sensitive to disruptions in cellular signaling. Perinatal complications, preterm birth, and exposure to environmental chemicals are systemic factors known to contribute to …
Read PDFThe trophectoderm produced from totipotent blastomeres initiates trophoblast development, while placental deficiencies can cause pregnancy disorders. Yet, a culture system that fully recapitulates the entire placenta development is still lacking, greatly limiting related studies. Here, …
Read PDFTung oil, obtained from the seeds of the tung tree (Vernicia fordii), holds significant economic value. Nevertheless, the low proportion of female flowers in tung trees limits tung oil yield. Studying the expression of genes …
Read PDFUnderstanding changes in gene expression and cell-cell signaling among spatial regions in diseased tissues adds critical biological information to understanding mechanisms. Here, we present a protocol to investigate molecular transcriptional drivers within intact murine tissue …
Read PDFA systematic dissection of the functional impacts of non-coding variations across diverse tissues and cell types is essential for deciphering the molecular architecture underlying complex traits. Given the significance of chickens as both a key …
Read PDFSalinity severely limits global crop productivity, prompting a need to uncover plant salinity adaptation strategies. Suaeda salsa (L.) Pall., a halophyte thriving in saline habitats, offers a valuable model to dissect plant growth mechanisms under …
Read PDFCancer functional genomics enables high-throughput target discovery and mechanistic investigation, yet its application has remained largely confined to mouse models and established human cancer cell lines. Direct functional interrogation of heterogeneous primary tumors offers a …
Read PDFFli1b is an ETS transcription factor, which has been previously implicated in zebrafish vascular and hematopoietic development. Here we present single cell RNA sequencing data from wild-type and maternal zygotic <i>fli1b</i> mutant zebrafish embryos at …
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