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<h4>Background</h4>Phosphatidylinositol transfer protein-1 (pitp-1) is involved in the phosphoinositide (PIP) cycle. The role of pitp-1 in promoting healthy longevity remains unknown. Our previous work showed that the PIP cycle-related genes diacylglycerol lipase-1 (dagl-1) and diacylglycerol …
Read PDF<b>Background:</b> Alternative promoter usage contributes to isoform diversity and gene regulation in mammals but remains difficult to study at scale. Cap Analysis of Gene Expression precisely maps transcription start sites, but its cost limits large-scale …
Read PDFGene expression is regulated through a complex interplay between transcriptional and post-transcriptional mechanisms, yet their relative contributions and relationships remain incompletely understood. In this study, we propose normalized metrics to quantify regulatory density at each …
Read PDF<h4>Introduction</h4>Drought negatively affects production in wheat, an important crop worldwide. Some <i>Trichoderma</i> spp. are of interest for sustainable agriculture. Upon plant root colonization, some strains produce multifaceted benefits for its host, including defence priming against …
Read PDFSpatial transcriptomics is an emerging technology that can analyze gene expression profiles of tissues while preserving spatial location information. To restore cell type proportions from mixed gene expression data, here we present DANST, a deconvolution …
Read PDFCellular RNA folds into complex helical structures that are attractive targets for controlling biological activity and treating diseases using RNA-binding ligands. Peptide nucleic acid (PNA) is a neutral DNA analog uniquely suited for triple-helical recognition …
Read PDFEmerging tolerance of <i>Schistosoma mansoni</i> to praziquantel, the only drug available for schistosomiasis treatment, highlights the need for new therapeutic targets. Snake venoms contain pharmacologically active proteins and peptides that can decrease the viability of …
Read PDF<h4>Introduction</h4><i>Xylella fastidiosa</i> is a phytopathogenic bacterium of worldwide importance causing detrimental diseases in several crops. Recent reports from European and Mediterranean countries raised great concerns and have given impetus to new studies investigating both the …
Read PDFStem lodging significantly reduces soybean yield stability, particularly under dense planting and intercropping systems. Stem breaking strength is a key component of lodging resistance, but its genetic basis remains incompletely understood. In this study, an …
Read PDFLimiting the level of piglet losses before weaning is a growing demand from producers and society to improve the welfare and health of sows and piglets. In particular, perinatal mortality, which can be defined as …
Read PDF<h4>Background</h4>Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by intense systemic inflammation and immune dysregulation, with monocytes playing a central role in its progression. Patients with HBV-ACLF typically receive comprehensive treatment including artificial liver …
Read PDFPolyamines (PAs) play critical roles in plant growth, somatic embryogenesis (SE), etc. Previous studies have demonstrated that exogenous PAs could promote SE in plants. However, the effects of PAs on <i>Ginkgo biloba</i> L. SE are …
Read PDFUnderstanding transcriptional regulatory networks (TRNs) in microglia is essential for elucidating mechanisms underlying central nervous system (CNS) disorders. Human induced pluripotent stem cell (iPSC)-derived models enable mechanistic studies of microglia but often suffer from variability …
Read PDFDeferiprone (DFP) is an iron chelator approved for treating iron overload in thalassemia patients. Recent observations have suggested that DFP has promising anticancer activities ascribed to several mechanisms, including reduction of the intracellular free labile …
Read PDFThere are a bewildering number of variables to consider when planning an RNA sequencing study (RNA-Seq). Here we discuss some of the considerations for an investigator initiating such studies, with a focus on library preparation, …
Read PDF<h4>Background</h4>Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties.<h4>Methods</h4>The activity of BCV was evaluated in 44 cell-line models, including T/NK-cell non-Hodgkin lymphoma (T/NK-NHL, n = 25) and B-cell lymphoma …
Read PDFBees are important pollinators that are increasingly threatened by viruses. In this study, we investigated the viruses in honey bees in Bangladesh, focusing on western (<i>Apis mellifera</i>) and native bee species (<i>A. cerana</i>, <i>A. dorsata</i>, …
Read PDF<h4>Introduction</h4>While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored.<h4>Methods</h4>We conducted a comprehensive analysis of RNA editing across nine human brain …
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