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Mitral valve disease (MVD), particularly mitral valve prolapse (MVP), is a common heart valve condition affecting millions of people worldwide. Its pathological mechanism is complex, involving multiple factors such as extracellular matrix remodeling, inflammatory responses, …
Read PDF[This corrects the article DOI: 10.3389/fimmu.2026.1810925.].
Read PDFExosomes play a crucial role in tumor progression. However, reliable exosome-related biomarkers for predicting prognosis in gastric cancer (GC) remain scarce. This study is aimed at developing an exosome-related gene risk signature (ERGRS) to predict …
Read PDF<h4>Background</h4>Acute myocardial infarction (AMI) represents a life-threatening cardiovascular emergency characterized by myocardial necrosis resulting from prolonged ischemia. <i>Erigeron breviscapus</i> (Vant.) Hand.-Mazz. (EB), a traditional Chinese medicinal herb, has demonstrated cardioprotective properties in clinical applications. This …
Read PDFMonitoring T cell repertoires in human tissues provides important insights into immune response mechanisms in cancer, infectious diseases, and autoimmunity. However, retrieving VDJ information from single-cell and spatial transcriptomics workflows with 3'-barcoding of cDNA remains …
Read PDFSpatial profiling technologies are revolutionising traditional research by enabling whole transcriptome and high-plex protein <i>in situ</i> analysis at scale. Profiling tissue microarrays permits multiple specimens to be analysed at once, but depending upon your research …
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Read PDFMycoheterotrophic plants rely entirely on fungal symbionts for nutrients, yet the role of intraspecific genomic variation in shaping symbiotic adaptation remains unclear. <i>Gastrodia elata</i> is a mycoheterotrophic orchid with multiple cultivated varieties. Here, we generated …
Read PDFFoodborne diseases present a serious public health challenge, causing roughly 600 million illnesses and 420,000 deaths annually. A significant portion of this impact is felt in Asia, where traditional fermented and dry-salted seafood, such as …
Read PDFBACKGROUND: Pig is an important model for biomedical studies, yet the immune cell heterogeneity, the subtle relationship between immune cells and the inter-breed immune variation in pigs remains poorly characterized. Here, we generate single-cell transcriptomes …
Read PDFDue to late diagnosis, high molecular diversity, and limited response to therapeutic intervention, gastrointestinal (GI) cancers result in a considerable number of cancer-related deaths. Classic clinicopathological classification and single omics analysis fail to adequately convey …
Read PDF<h4>Background</h4>Esophageal cancer is a highly aggressive malignancy with poor prognosis and limited molecular markers for effective risk stratification and therapeutic guidance. Mitochondrial stress-related pathways are increasingly recognized as important regulators of tumor progression and immune …
Read PDF<h4>Introduction</h4>Uterine fibroids are the most common benign gynecological tumors, affecting up to 70-80% of women, yet still lack clinically validated biomarkers for disease stratification, monitoring, or therapeutic targeting. Advances in multi-omics technologies offer unprecedented opportunities …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) is a genomically heterogeneous malignancy with substantial variability in prognosis and therapeutic response. Pseudouridine (<i>Ψ</i>) modification is an evolutionarily conserved RNA modification involved in RNA structure stabilization and translational regulation; however, the …
Read PDFThe accuracy of spatial gene expression profiles generated by probe-based in situ spatially resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe …
Read PDFPharmacogenomics AI offers significant potential for individualized drug therapy; however, its clinical benefits remain unevenly distributed. Models trained predominantly on European-ancestry data consistently underperform in non-European populations, with polygenic risk scores (PRS) showing an estimated …
Read PDFAlternative splicing is an essential mechanism for generating protein diversity by producing distinct isoforms from a single gene. Dysregulation of splicing that affects pancreatic function and immune tolerance has been linked to both types 1 …
Read PDFPrevious studies on the characterization of regulatory T cells (Tregs) in the thymus have proven to be simplistic. Here, we present a protocol for identifying recirculating thymic Tregs in mice and characterizing the role of …
Read PDF<h4>Background</h4>Head and neck squamous cell carcinoma (HNSC) exhibits substantial prognostic and microenvironmental heterogeneity. However, the integrated prognostic relevance of synergistic immune and inflammatory signatures in HNSC remains fully elucidated.<h4>Methods</h4>Weighted gene coexpression network analysis (WGCNA) was …
Read PDFThe Chicken Genotype-Tissue Expression (ChickenGTEx) project was established to systematically characterize the regulatory landscape of the chicken genome and to accelerate the translation of functional genomics into precision breeding. By integrating whole-genome sequencing with multi-tissue …
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