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<b>Background</b>: Diabetic vascular complications are a major cause of poor prognosis in patients with diabetes mellitus (DM). Mitophagy activation is a potential therapeutic target for type 2 diabetes mellitus (T2DM), but the role of low-intensity …
Read PDFFollowing a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-histidine monohydrochloride monohydrate produced with a genetically modified strain of <i>Escherichia coli</i> (CCTCC M …
Read PDFBACKGROUND: Hypertension (HTN) results from intricate molecular mechanisms, making clinical remission difficult to achieve. This study explores the molecular pathways through which cannabidiol (CBD) may influence HTN. METHODS: Several RNA sequencing datasets related to HTN …
Read PDFAccurate prediction of MHC-peptide binding affinity remains a challenge for immunotherapeutic development. Existing methods struggle to jointly model functional semantics of polymorphic residues, evolutionary conservation constraints, and structural dynamic. We propose the Contrast learning-based Multi-feature …
Read PDF<h4>Background</h4>Periodontal disease, a chronic inflammatory disorder, is increasingly linked to systemic conditions. This study investigates its causal role in muscle wasting via chronic inflammation, aiming to inform integrative therapeutic strategies.<h4>Methods</h4>Mendelian randomization (MR) analysis was applied …
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Read PDF[This retracts the article DOI: 10.1155/2021/5445349.].
Read PDF<i>Glochidion puberum</i> (L.) Hutch., a member of the family Phyllanthaceae, is widely distributed in China and possesses both medicinal and ornamental value. Despite its ecological and economic significance, the complete chloroplast genome of <i>G. puberum</i> …
Read PDF<i>Streptomyces</i> sp. CLCI03 and <i>Pseudomonas</i> sp. CLCA07 were isolated from soil suspensions cultured on chitin-amended Winogradsky medium. Whole-genome analyses of these two strains revealed genome sizes of 8.68 and 6.73 Mb with G + C …
Read PDFThe shift of artificial intelligence for antimicrobial resistance (AI-AMR) from proof-of-concept studies to clinically embedded decision support critically hinges on establishing rigorous reproducibility, interpretability, and evaluation standards aligned with antimicrobial stewardship and patient safety. This …
Read PDFThe human gut microbiota, particularly the intestinal microbiota, shapes host physiology, disease risk, and therapeutic outcomes through complex metabolic and enzymatic activities. Recent advances in molecular omics, metabolomics, enzyme bioinformatics, and artificial intelligence (AI) have …
Read PDF<h4>Introduction</h4>Immunotherapy with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis has become an established treatment strategy across various malignancies. In this context, PD-L1 expression plays a key role in the clinical management of cancer patients. …
Read PDF<h4>Motivation</h4>The discovery of novel drug targets and precision biomarkers remains a major challenge in drug development, with traditional differential expression analysis often overlooking key regulatory proteins. Here, we present a novel, web-based bioinformatics tool, the …
Read PDF<h4>Background</h4>Circular RNA (hsa_circ_0070354), also known as circPTPN13, was demonstrated in our previous study that it can be used as a biomarker for diagnosing non-small cell lung cancer (NSCLC). However, the mechanism of its role in …
Read PDFThe AlphaFold Protein Structure Database (AFDB; https://alphafold.ebi.ac.uk), developed by EMBL-EBI and Google DeepMind, provides open access to hundreds of millions of high-accuracy protein structure predictions, transforming research in structural biology and the wider life sciences. …
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