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We announce the draft genome sequence of <i>Streptococcus gallolyticus</i> strain AAM02, isolated from traditional fermented milk (doi) collected in Bogura, Bangladesh (GPS: 24.85°N, 89.37°E) in 2023. The genome provides insights into its genetic adaptations to …
Read PDFIn this study, we determined and analyzed the complete mitochondrial genome of <i>Aphlugiolopsis trapeziformis</i>. The mitogenome of <i>A. trapeziformis</i> (length: 16,766 bp) is double-stranded circular. It contains the 37 typical mitochondrial genes (13 protein genes, …
Read PDFThe Genome Variation Map (GVM; https://ngdc.cncb.ac.cn/gvm) serves as a public repository for genetic variation data. This version represents a major upgrade to GVM, integrating rigorously curated high-quality DNA resequencing data from a wide range of …
Read PDFSesame (Sesamum indicum L.) is a globally important oilseed crop, but its production is constrained by charcoal rot, caused by the soil-borne fungus Macrophomina phaseolina. The pathogen's exceptionally broad host range, long-term soil persistence through …
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Read PDFWe report the draft genome sequence of <i>Enterobacter</i> sp. strain I4, an endophytic bacterium isolated from healthy <i>Aloe barbadensis</i> Miller leaves and stems. The 4.7-Mb genome (56.5% GC) comprises three contigs and encodes 4,339 predicted …
Read PDFNon-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses.
Read PDFThe American College of Medical Genetics and Genomics (ACMG) recommends Tier-3 reproductive carrier screening for 97 genes associated with autosomal recessive (AR) conditions (AR genes). Gene selection for screening is based on a gene carrier …
Read PDFRNA molecules form homotypic clusters in a variety of contexts. mRNAs enriched in germ granules in <i>Drosophila</i> embryos are a canonical example, with <i>polar granule component</i> (<i>pgc</i>) mRNAs colocalized with other <i>pgc</i> mRNAs, and <i>nanos</i> …
Read PDFOBJECTIVE: Clarify the shared genetic architecture between Alzheimer’s disease (AD) and major psychiatric disorders. METHODS: We integrated large GWAS summary datasets derived predominantly from individuals of European ancestry for AD and eight psychiatric disorders; estimated …
Read PDF<h4>Background</h4>Thrombotic events, including acute ischemic stroke, are more common in individuals with congenital heart disease (CHD). Whether common thrombophilia variants contribute to thrombotic risk in this population remains unclear. We evaluated whether prothrombin G20210A (<i>F2</i> …
Read PDF<i>Lactococcus petauri</i> is an emerging fish pathogen linked to septicemia. We report draft genome sequences of two <i>L. petauri</i> isolates from independent lactococcosis outbreaks in Mexican fish farms. This study confirms <i>L. petauri</i> presence in …
Read PDFSepticemia remains a major cause of death in intensive care units and its treatment is increasingly challenged by multidrug-resistant pathogens. This study investigated bloodstream infections in 89 ICU patients at a tertiary hospital in Sikkim …
Read PDF<h4>Background</h4>The integration of genomics into Australian health services offers significant benefits for the diagnosis and delivery of targeted treatments, but its success relies on a workforce equipped to deliver genomic-informed care. Nurses and midwives, Australia's …
Read PDFSocial insects are key models for phenotypic plasticity, as queens and workers show striking differences in behaviour and lifespan despite sharing the same genome. Neuropeptides are central regulators of behavioural plasticity, and caste-specific ageing is …
Read PDF<h4>Objective</h4>The involvement of methyltransferase-like 3 (METTL3, an m6A methyltransferase) and the PI3K/AKT pathway in tumor progression and immune regulation remains poorly understood. This study investigates whether METTL3 influences the immune microenvironment of renal cell carcinoma …
Read PDFInvestigating the genetic architecture of complex diseases is challenging due to the multifactorial interplay of genomic and environmental influences. Although GWAS have identified thousands of variants for multiple complex traits, conventional statistical approaches can be …
Read PDFThe Electronic Medical Records and Genomics (eMERGE) Network developed and implemented a genome-informed risk assessment (GIRA) to communicate genomic (polygenic risk scores [PRSs], integrated risk scores [IRSs], and monogenic results), clinical, and family history-based risk …
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