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<i>Brucella abortus</i> is a globally significant zoonotic pathogen. To explore the functional relevance of its genes in acidic, oxidative, and antimicrobial stress conditions, we constructed high-density transposon sequencing libraries in the attenuated <i>B. abortus</i> S19 …
Read PDF[This corrects the article DOI: 10.3389/fgene.2025.1563544.].
Read PDFNow in its 25th year of operation, the UCSC Genome Browser (https://genome.ucsc.edu) provides a central location for researchers around the world to display and compare annotations on assembled genomes. Highlighted updates include a positional heatmap …
Read PDF<h4>Background</h4>Biomedical research effort is distributed highly unevenly across human genes, with a small subset dominating the scientific literature while thousands remain sparsely studied. Whether this imbalance reflects intrinsic biological importance or historically reinforced research bias …
Read PDFThe red flour beetle Tribolium castaneum yielded the first resolved telomerase reverse transcriptase structure but lacked a known telomerase RNA. We identify two telomerase RNA paralogs in Tribolium, confirm their expression, and reconstitute active telomerase …
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Read PDFMaize germplasm is fundamental for breeding progress, yet the genetic and phenotypic trajectories of China’s modern commercial hybrids are poorly characterized. Through whole-genome resequencing of the hybrids themselves—which directly represent commercially deployed varieties— and multi-trait …
Read PDF<i>Cronobacter muytjensii</i> is a gram-negative bacterium associated with public health concerns. Here, we report the characterization of cronophage vB_Cmu_VP5. Genome analysis indicates that vB_Cmu_VP5 is a member of the class Caudoviricetes. The genome contains 47 …
Read PDFExposomics has the potential to revolutionize biomedical research. However, the transition from hypothesis-driven to discovery-driven research has created tension between expansive screening and the risk of false discoveries. To meet the rigorous expectations of funders, …
Read PDF<h4>Objectives</h4>Polygenic risk scores are increasingly available to consumers to provide an estimate of the genetic contribution to health conditions. However, healthcare providers report limited knowledge and confidence using polygenic risk scores. Clinical implementation necessitates educational …
Read PDFEffective diagnosis and treatment of rare genetic disorders requires the interpretation of a patient's genetic variants of unknown significance (VUSs). Today, clinical decision-making is primarily guided by gene-phenotype association databases and DNA-based scoring methods. Our …
Read PDFComprehensive genomic testing in routine cancer care pathways has created the need to interpret the consequences of somatic (acquired) genomic variants beyond the currently well-characterised driver variants in cancer gene hotspots. While several guidelines have …
Read PDFTrastuzumab, pertuzumab, and a taxane (THP) has been the standard first-line therapy for HER2+ advanced breast cancer for over a decade. With new regimens emerging, genomic tools like HER2DX may help identify patients who benefit …
Read PDFPseudomonas species are globally distributed bacteria that influence soil and plant health, functioning as both pathogens and plant growth-promoting rhizobacteria (PGPR). Genomic analyses have revealed the genetic basis for their ecological versatility, including the evolution …
Read PDFThe bovine respiratory disease (BRD) complex is a major health and welfare challenge in the cattle industry worldwide, with substantial economic and antimicrobial resistance implications. <i>Pasteurella multocida</i> (PM) is a key bacterial agent of BRD; …
Read PDFDespite drastic advances in psychiatric genetics, comparatively little attention has focused on the translation of those discoveries into real-world impact. This paper reviews the processes and considerations for integrating new techniques into clinical practice and …
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