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We report the complete genome sequence of <i>Cysteiniphilum</i> strain GTC20157 isolated from coastal seawater in Osaka, Japan. The genome comprised a circular chromosome and a circular plasmid measuring 2,508,673 and 149,142 bp, respectively.
Read PDF<b>Background</b> <i>. Klebsiella pneumoniae</i> (<i>Kpn</i>) is an important cause of healthcare-associated infections (HAIs). In low- and middle-income countries, HAI due to <i>Kpn</i> disproportionately affects neonates. In this study, we investigated the genomic changes that occurred …
Read PDFMany diseases are caused by pathogenic expansion of microsatellite repeats. Longread sequencing allows evaluation of the content of such expanded repeats. Friedreich ataxia patients are typically homozygous for an expanded GAA repeat in intron 1 …
Read PDFSequencing of the <i>Lacticaseibacillus rhamnosus</i> NS2301G1 strain isolated from kimchi revealed a 2,968,519 bp circular chromosome with a 46.74% GC content; in addition, genes linked to probiotic properties, stress tolerance, and carbohydrate metabolism were identified, …
Read PDF<i>Ekhidna algicida</i> To15<sup>T</sup> was isolated from the Tropical Pacific Ocean, based on its algicidal effect on the pelagic diatom <i>Thalassiosira oceanica</i>. We report the complete genome sequence, comprising one chromosome for this newly discovered species …
Read PDFThe genus <i>Eubacterium</i> comprises gram-positive anaerobic bacteria. It has long been recognized as a component of human oral and gut microbiota. Here, we report the complete genome sequence of a novel strain, <i>Eubacterium brachy</i> GTC …
Read PDFNon-tuberculous mycobacteria are emerging respiratory pathogens that can persist in treated water systems. In 2018, a cluster of <i>Mycobacterium intracellulare</i> lung infections was linked to a pool facility in Australia, prompting an epidemiological and genomic …
Read PDFWe report the complete genome sequences of five <i>Variovorax</i> strains isolated from the roots of <i>Populus</i> species in greenhouse and field settings. Genome sizes range from 7.44 to 7.71 Mbp and encode 6,077-6,879 predicted protein-coding …
Read PDF<h4>Objectives</h4>Carbapenemase-producing Enterobacterales (CPE) represent a serious health care concern and their spread in animals has become alarming. Following several cases of CPE infections in a companion animal clinic, the role of the clinic backyard lawn …
Read PDFEndogenous DNA damage from metabolism and genome dynamics drives mutation, instability, and disease. New insights from ACS Fall 2025 reveal chemical diversity, metabolic drivers, and repair limits that shape cancer risk and biomarker development.
Read PDFHealthcare, and the world at large, are currently facing an antibiotic crisis caused by the increase in antibiotic resistant bacterial pathogens, combined with divestment in the drug discovery pipeline for new antibiotics. The Tiny Earth …
Read PDF<i>Aeromicrobium</i> sp. JP4, an efficient degrader of polyurethane plastic, was isolated from a plastic waste dumpsite of Nanjing City, Jiangsu Province, China. We report the complete genome sequence of strain JP4, which consists of a …
Read PDFMobile genetic elements (MGEs) play a central role in the acquisition and dissemination of antibiotic resistance genes (ARGs). This study analyzed the distribution of MGEs using the whole-genome sequences of 38 <i>Acinetobacter</i> isolates from patient, …
Read PDFBACKGROUND: Traditionally, Pseudonectria foliicola has been considered to have high host specificity, mainly infecting boxwood and causing typical leaf spot disease, with little threat to human health. However, in 2024, the first case of human …
Read PDFData quality is the foundational to scientific research and the rapid advancement of artificial intelligence. Ensuring data quality, provenance, and reproducibility requires robust mechanisms for traceability and accountability from the moment data are created. We …
Read PDFGDSL esterase/lipase (GELP) proteins constitute an evolutionarily conserved yet functionally diversified hydrolase family in land plants. They participate in cuticle and secondary cell wall biosynthesis, seed lipid remobilization, reproductive development, and hormone-mediated responses to biotic …
Read PDF<h4>Background</h4>Traditional infectious disease surveillance systems face significant limitations, including delayed detection, underreporting of asymptomatic cases, and inequitable health care access. Wastewater-based epidemiology (WBE), enhanced with genomic analysis, offers a noninvasive and cost-effective alternative for early …
Read PDF<h4>Introduction</h4>Genomic testing allows for the identification of disease-causing genetic variants and may also reveal secondary findings (SF) unrelated to the reason for testing. As the list of medically actionable genes continues to grow, it is …
Read PDFLung cancer is the highest global incidence and mortality rates, imposing substantial burdens on patients’ lives. As the most transformative technology of the modern era, artificial intelligence (AI) has been deeply integrated into medical research …
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