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<h4>Introduction</h4>Men generally have higher plasma uric acid (PUA) concentrations and are at greater risk for hyperuricemia-related diseases. Sex hormones may underlie this difference, though mechanisms remain unclear. Sex hormone therapy offers a unique opportunity to …
Read PDFDiabetic nephropathy (DN) represents the predominant microvascular complication associated with diabetes mellitus; however, existing diagnostic techniques are inadequate. This study evaluated candidate urinary protein biomarkers for diagnosing DN. A cohort comprising 59 patients with type …
Read PDFKinase inhibitors represent a vital class of therapeutic agents widely used in cancer research, immunology, and other disease areas. Mass spectrometry (MS) employing specially designed small-molecule kinase-binding probes has become an essential strategy for identifying …
Read PDFPleural Mesothelioma (PM) is an aggressive cancer that attacks thousands of people every year. One of the common treatments is surgery to remove the tumor. Unfortunately, around 11% of patients die from blood clots post-surgery. …
Read PDFPSLite Online is a modern, web-based application designed to facilitate the analysis of top-down mass spectrometry fragmentation data, particularly for targeted proteoform studies. As a successor to the Windows-only ProSight Lite, PSLite Online retains and …
Read PDFAspirin (Asp) therapy reduces the risk of arterial thrombotic events. However, aspirin-related adverse effects, particularly cerebral hemorrhage with its high mortality and disability rates, remain a significant concern. Interestingly, long-term antiplatelet therapy does not appear …
Read PDFInsulin resistance (IR) links obesity to metabolic disorders. While weight loss reverses IR, we show that calorie reduction (CR) can do so in obese mice within a day before significant weight loss. In contrast to …
Read PDFObesity, sarcopenia, malnutrition, and cachexia all include assessment of body composition in their respective clinical guidelines, although patient evaluations frequently require hardware that may not be available. Body mass index often fills this void, but …
Read PDFAlzheimer's disease (AD) is the leading cause of dementia and represents a progressive, irreversible neurodegenerative disorder. Given the complexity and heterogeneity of AD, which involves numerous interrelated molecular pathways, large-scale proteomics datasets are essential for …
Read PDF<h4>Background</h4>Due to its proximity to cells of the central nervous system, cerebrospinal fluid (CSF) is an important source of novel biomarkers for neurological diseases. Membrane-bound extracellular vesicles (EVs) are enriched for proteins of intracellular and …
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Read PDF<h4>Abstract</h4>Central nervous system (CNS)-hemophagocytic lymphohistiocytosis (HLH) can mimic other neuroinflammatory disorders (ONID), often leading to misdiagnosis. Current diagnostic studies do not reliably distinguish CNS-HLH from ONID. We hypothesized that novel cerebrospinal fluid (CSF) biomarkers identified …
Read PDFNeoadjuvant chemotherapy (NACT) is the standard treatment for muscle-invasive bladder carcinoma (MIBC), but its efficacy varies significantly among patients. The aim of this study is the identification of biomarkers and biological processes related to the …
Read PDFAccurate identification of prognostic cancer subtypes remains challenging using routine diagnostics alone. Here, we present a protocol to obtain isocitrate dehydrogenase (IDH)-mutant astrocytoma subtype predictions using the generic utility for immune/mesenchymal-enriched (IME) diagnostic estimation (GUIDE). …
Read PDFMycobacterium tuberculosis is the causative pathogen of human tuberculosis and a leading cause of death worldwide attributed to a single infectious agent. While small non-coding RNAs (sRNAs) have emerged as key regulators of bacterial pathogenicity, …
Read PDFWe present a pilot, single-subject longitudinal analysis of plasma antibodies and proteome dynamics across 310 days spanning COVID-19 vaccination and subsequent SARS-CoV-2 infection. Serial plasma samples were analyzed by DIA-LC-MS/MS, identifying 1502 proteins. Comparative analyses …
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