Antibody profiling and plasma proteomics in SARS-CoV-2 infection: a pilot study

We present a pilot, single-subject longitudinal analysis of plasma antibodies and proteome dynamics across 310 days spanning COVID-19 vaccination and subsequent SARS-CoV-2 infection. Serial plasma samples were analyzed by DIA-LC-MS/MS, identifying 1502 proteins. Comparative analyses across key intervals (pre-vaccination, post-dose 1, post-dose 2, and post-infection) showed minimal proteomic shifts after vaccination but distinct, coordinated expression changes after SARS-CoV-2 infection.