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<i>Klebsiella pneumoniae</i> carbapenemase-producing <i>K. pneumoniae</i> (KPC-Kp) are high-priority pathogens. Although meropenem/vaborbactam is a preferred treatment, resistance can emerge. Two KPC-Kp isolates from the Centers for Disease Control and Prevention(CDC) Antimicrobial Resistance Isolate Bank were sequenced …
Read PDFSpatial transcriptomics (ST) integrates gene expression with spatial context to study tissue pathology. We present SPaSE (spatially resolved pathology score), a protocol to quantify pathology by computing an optimal transport plan between ST spots of …
Read PDFBACKGROUND: Understanding the genetic basis of adaptation to extreme environments is crucial in evolutionary biology. Gannan Tibetan sheep, which thrive in high altitudes with thin air and cold climates, demonstrate remarkable resilience. However, the genetic …
Read PDFArtisanal and small-scale gold mining has rapidly reshaped southeastern Senegal's Kédougou region from a sparsely populated savanna-forest landscape into a highly connected frontier marked by land-use change, intense population mobility, and fragile basic services. Over …
Read PDFBrood parasitism is a significant reproductive strategy among birds. Both the Scaly-sided Merganser (Mergus squamatus) and the Mandarin Duck (Aix galericulata) are tree-cavity-nesting waterbirds with overlapping ecological niches. Although field observations have previously suggested that …
Read PDFLung cancer is one of the most common cancers worldwide and one of the leading causes of cancer death, with a heavy disease burden and severe public health challenges. Multi-omics techniques, such as genomics, proteomics, …
Read PDFLaura Veschetti works in the field of microbial genomics and adaptation. In this mSphere of Influence article, she reflects on how the work of Marvig et al. on within-host evolution of <i>Pseudomonas aeruginosa</i>, together with …
Read PDFAnthracnose, caused by <i>Colletotrichum lindemuthianum</i>, is a major threat to dry beans (<i>Phaseolus vulgaris</i>), causing significant yield losses worldwide. Despite considerable progress in breeding resistant varieties using traditional methods such as phenotypic selection and crossbreeding, …
Read PDFPhage-plasmids are unique mobile genetic elements that function as plasmids and temperate phages. While it has been observed that such elements often encode antibiotic resistance genes and defense system genes, little else is known about …
Read PDFDeciphering how human T cells recognise peptide-HLA (pHLA) complexes underpins next-generation vaccines and personalised immunotherapies, yet extreme sequence diversity and paired-chains interdependence still hamper reliable in silico prediction of T-cell receptor (TCR) specificity. To overcome …
Read PDFOvarian cancer (OC) is a predominant cause of fatality amongst gynecological malignancies, frequently identified at its later stages owing to its asymptomatic characteristics and the absence of adequate screening techniques. Imaging techniques such as ultrasound …
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Read PDFBACKGROUND: The adoption of whole genome and exome sequencing (WGS/WES) is expanding rapidly, yet variant interpretation remains a critical bottleneck, limiting diagnostic yield and delaying precision care. We present ACVI-Med (Accelerated Candidate Variant Interpretation in …
Read PDFWe present the first complete genome of <i>Eurhaphidophora fossa</i> from China. The mitochondrial genome of E. fossa is 15892 bp in length, exhibiting high AT-rich bias (75.2%). It includes 13 protein-coding genes, 2 ribosomal RNA …
Read PDFGenetic practices are increasingly recognised as essential components of modern healthcare. Allied health professionals and nurses are ideally placed to initiate discussions about genetic investigations with patients and families. However, there are known barriers such …
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