Full text 2026

Complete genome sequences of KPC-producing <i>Klebsiella pneumoniae</i> isolates pre- and post-development of meropenem/vaborbactam resistance

Ozer EA, Nozick SH, Singh N, et al.

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Abstract

<i>Klebsiella pneumoniae</i> carbapenemase-producing <i>K. pneumoniae</i> (KPC-Kp) are high-priority pathogens. Although meropenem/vaborbactam is a preferred treatment, resistance can emerge. Two KPC-Kp isolates from the Centers for Disease Control and Prevention(CDC) Antimicrobial Resistance Isolate Bank were sequenced before and after development of meropenem/vaborbactam resistance following treatment with this antibiotic in the hollow fiber infection model (HFIM).

Keywords

Klebsiella pneumoniae Antibiotic Resistance Beta-lactamases Kpc Meropenem/vaborbactam