Search the literature by keyword, topic, or author. Filter to articles with full text available.
3689 results
<h4>Background</h4>Cisplatin (DDP), as a commonly used chemotherapeutic agent for the clinical treatment of lung adenocarcinoma (LUAD), serves a key function in suppressing tumor progression; however, the development of tumor cell resistance has restricted its clinical …
Read PDFMany long-standing questions in population genomics can now be addressed through comparative analyses and by leveraging the vast amount of genomic data being generated. In the context of questioning the utility of producing such a …
Read PDFWe analyzed respiratory syncytial virus genome sequences from adults in Georgia, USA, during 2024-2025. We found multiple co-circulating lineages of both A and B subtypes. We identified few mutations in F protein antigenic sites in …
Read PDFGenomic medicine is increasingly being integrated into healthcare systems worldwide, requiring a skilled genomic workforce. Variant interpretation (VI) is crucial to genomic testing, yet there are no agreed professional competencies in VI, career pathways are …
Read PDFBACKGROUND: Plants are increasingly considered as secondary reservoirs for enterics. However, little is known about their population dynamics and the genetic mechanisms during plant colonization. Clostridium butyricum is a gut symbiont of humans and animals …
Read PDFFungal antimicrobial resistance (fAMR) is increasing worldwide and is recognized as a global health priority by the World Health Organization. The emergence of <i>Candidozyma (Candida) auris</i> and other resistant fungal pathogens presents a risk to …
Read PDF<h4>Background</h4>Patients with clinical characteristics of increased cancer susceptibility without an identified genetic lesion are regularly seen in clinics. Association studies and matched normal/tumour sequencing have advanced the discovery of Cancer Susceptibility Genes (CSGs), with limitations …
Read PDFThe Generation Study is a large-scale research initiative led by Genomics England in partnership with the National Health Service, aiming to evaluate the use of whole genome sequencing in newborn screening, as well as ongoing …
Read PDFBACKGROUND: Classic Homocystinuria (HCU) is the second most treatable aminoacidopathy. It affects multiple organs in varying degrees, and early recognition and treatment is crucial to improve the prognosis. Mutations in the CBS gene result in …
Read PDFMicrobial ecology has entered a phase of methodological consolidation where genomic and molecular tools are being used to address ecological questions rather than being subordinate to culture-based approaches [...].
Read PDFAntimicrobial peptides (AMPs) are key components of plant innate immunity, offering broad spectrum protection against pathogens and represent promising alternatives to chemical pesticides for sustainable crop protection. Despite their broad range antimicrobial activity and low …
Read PDFNo abstract available.
Read PDFParasitic plants have evolved independently at least a dozen times across angiosperms, yielding some of the most extreme examples of genomic reconfiguration in plants. Comparative analyses of plastid, mitochondrial, and nuclear genomes reveal striking convergence …
Read PDF<h4>Introduction</h4>"Population Health Management (PHM), Fit Lifecycles in Analytics" examines the policy and practice of AI-driven methodologies to enhance public health and patient safety in the context of the Human Phenotype Ontology (HPO). It aims for …
Read PDFTheoretical prediction of topological superconductivity is key to their discovery. Recently, it is proven that in 199 out of 230 space groups, topological superconductivity coexists with an s-wave-like pairing symmetry, raising the hope of finding …
Read PDFMulti-omics in combination with advanced computational methodologies synthesizes diverse omics data to provide deeper insights into molecular interactions and offers transformative potential for unravelling phenomenon behind disease complexities, improving diagnostics, disease prevention, and personalized treatments. …
Read PDF<h4>Background</h4>The clinical phenotype and pathogenic mechanism of 46,XY disorders of sex development (DSD) are complex, and several pathogenic variants are identified by next-generation sequencing. However, these variants currently require additional interpretation and validation prior to …
Read PDF