Human Respiratory Syncytial Virus in Vaccinated and Unvaccinated Adults, Georgia, USA, 2024-2025

We analyzed respiratory syncytial virus genome sequences from adults in Georgia, USA, during 2024-2025. We found multiple co-circulating lineages of both A and B subtypes. We identified few mutations in F protein antigenic sites in this population with low vaccine uptake, highlighting the need for ongoing genomic surveillance.