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Food security is increasingly threatened by climate change and population growth. Sweet potato has become a crucial crop for ensuring food security due to its adaptability to marginal lands and high yield potential. However, its …
Read PDFThe ongoing evolutionary struggle between crops and pathogens has highlighted the limitations of resistance gene (<i>R</i> gene)-based control, which often fails due to rapid pathogen adaptation. To address this, we must look beyond R genes …
Read PDFSystems biology is primarily concerned with the dynamic study of biochemical metabolic processes in physical systems, the interplay of multiple signal transduction routes, gene regulatory networks, and disease causes, among other things. Its most notable …
Read PDF<h4>Introduction</h4>Finding new uses for existing drugs, known as drug repurposing, is a widely adopted drug development strategy in the pharmaceutical industry. Computational drug repurposing leverages vast biomedical data to prioritize repurposing candidates. Once these candidates …
Read PDFAutoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current management is largely supportive or replacement based, there is …
Read PDFGenome-scale gene expression analysis has become a standard approach for discovering biomarkers and understanding molecular mechanisms. Recent advances in omics technologies now enable investigations beyond conventional case-control comparison and standard gene-centric differential expression (DE) analyses. …
Read PDFThe spatial distribution of immune cells in the tumor microenvironment (TME) is a key determinant of immunotherapy response, while current methods are limited by sequencing dependence and restricted spatial resolution. We developed SpaHE-Infil, a multimodal …
Read PDFClinical and biological insights from large-scale omics data are often limited by technical variability and analytical complexity. Here, we present BioinAI, a comprehensive framework that integrates an intelligent system with two algorithms, DeepAdvancer and stNiche, …
Read PDFSpaFun is a novel, non-model-based method developed to address limitations in existing spatially variable gene detection techniques, particularly for large-scale spatially resolved transcriptomics datasets. These limitations include computational inefficiency, limited statistical power with increasing data …
Read PDFSpatial transcriptomics enables detailed mapping of gene expression within tissues, revealing spatial organization of cellular and molecular processes. However, generating such data is costly and technically challenging, and analysis requires advanced bioinformatics skills. Although public …
Read PDFLipidomics involves the analysis of hundreds or even thousands of lipids within biological systems. Many of these lipids are highly correlated due to similarities in structure or relationships within metabolic pathways. Eigenlipids, as a concept …
Read PDFMoll glands, found in the margin of the eyelid next to the base of the eyelashes, are likely to play an important role in maintaining the tear film and therefore in securing adequate visual function. …
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