Biotic Stress Resistance in Sweet Potato: Mechanisms, Perspectives, and Sustainable Production Strategies

Food security is increasingly threatened by climate change and population growth. Sweet potato has become a crucial crop for ensuring food security due to its adaptability to marginal lands and high yield potential. However, its sustainable production is severely limited by diverse biotic stresses (including fungi, viruses, nematodes, insect pests and bacteria), which cause substantial yield losses. Despite its considerable importance, the key bottlenecks in this field remain unresolved, including the incomplete elucidation of core resistance mechanisms, unclear molecular regulatory networks underlying defense responses, insufficient understanding of crosstalk among multiple stresses, and limited integration of emerging technologies into practical resistance breeding. This review synthesizes the latest advances over the past two years. We dissect sweet potato's defense mechanisms from multiple dimensions and provide novel insights into biotic stress resistance gene regulatory networks. Given that sweet potato production faces the combined effects of multiple pests and biotic-abiotic stresses, we elaborate on the complex stress interactions in sweet potato. In addition, we propose biotic stress management strategies and a ten-year cultivar improvement roadmap that leverages the potential of emerging technologies, including artificial intelligence (AI), gene editing, novel omics approaches and synthetic biology. Taken together, with continuous intensification of global biotic stress challenges, systematic multi-dimensional strategies are imperative to alleviate biotic stress-associated yield and quality impairment in sweet potato. On this basis, this review provides a valuable theoretical and practical reference for resistance breeding and the sustainable production of sweet potato.