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3689 results

Full text 2025

An annotated chromosome-level genome of a troglophilic spider (Pimoa clavata)

Zhang Y, Zhang X, Jiang T, et al.

Climatic upheavals throughout Earth's history have driven species to subterranean refugia, where stable microclimates buffer environmental extremes. The spider family Pimoidae, relict lineages sensitive to thermal fluctuations, exemplifies this climate-driven habitat transition. Here, we present …

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Bioinformatics
Full text 2026

PCNE: A Tool for Plasmid Copy Number Estimation

Bollini R, Cento V.

The identification of plasmids from assembled genomes is well supported by numerous different tools, yet very few incorporate a plasmid copy number estimation step. This limits a comprehensive plasmid analysis, often leaving researchers to perform …

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Bioinformatics Genome Assembly Structural Variants
Full text 2026

Draft genome sequence of <i>Lacticaseibacillus paracasei</i> isolated from fermented banana pseudostem: genomic insights into probiotic and anti-diabetic potential

Bhanu R B P, Jayaram L, V S GD, et al.

<i>Lacticaseibacillus paracasei</i> RAMULABWGS01 was isolated from fermented banana pseudostem and sequenced to explore its functional, probiotic, and anti-diabetic potential. Genomic DNA was isolated & whole-genome sequence (WGS) using the Illumina NovaSeq platform. The assembled draft …

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Bioinformatics
Full text 2026

genCRC32: collision-free CRC32-based hashing of DNA sequences

Beran P, Rost M, Beranová K, et al.

<h4>Motivation</h4>Efficient and collision-free hashing of DNA sequences is essential for accuracy and performance in bioinformatics applications such as genome assembly, sequence alignment, and metagenomic classification. Traditional hashing methods often result in collisions, impacting the precision …

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Bioinformatics Metagenomics
Full text 2026

Whole-genome analysis of a multidrug-resistant Klebsiella michiganensis environmental isolate from an orthopedic ward in Mwanza, Tanzania reveals IncF-family plasmid replicon signatures associated with resistance determinants

Mboowa G, Kidenya BR, Sserwadda I, et al.

<h4>Background</h4>Klebsiella michiganensis, a member of the Klebsiella oxytoca species complex, is increasingly recognized in healthcare-associated infection and can persist in hospital environmental reservoirs. However, genome-resolved data on environmental K. michiganensis from Africa remain limited.<h4>Methods</h4>We performed …

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Bioinformatics
Full text 2025

A haplotype-resolved genome assembly of Anoectochilus roxburghii

Xu W, Gao M, Wang R, et al.

Anoectochilus roxburghii, a highly valued medicinal plant in traditional Chinese medicine, exhibits unique pharmacological properties and broad application value. In this study, we de novo assembled and annotated haplotype-resolved chromosome-level genomes of A. roxburghii cultivar …

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Bioinformatics Genome Assembly
Full text 2026

Prompt-based bioinformatic pipeline generation for a multi-step metaviral workflow

Ma P, Zheng H, Yi W, et al.

<h4>Motivation</h4>The rapid evolution of bioinformatics tools and multi-step analytic procedure presents a challenge for building effective pipelines, particularly for researchers without extensive programming expertise. This study demonstrates that large language models (LLMs) hold strong potential …

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Bioinformatics